grant
Regulatory T Cells and Lymphatic Endothelial Cells: Regulatory Interactions for Migration and Suppression
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AdenosineAdhesion MoleculeAffectAreaAutoregulationB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2B7-1B7-H1BB1BCDFBSF-2BSF2Basal Transcription FactorBasal transcription factor genesBindingBiologicalBloodBlood Reticuloendothelial SystemBody TissuesCD25CD274CD28LGCD28LG1CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD80CD80 geneCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell CommunicationCell Communication and SignalingCell ComponentsCell FunctionCell InteractionCell JunctionsCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell SignalingCell StructureCell surfaceCell-to-Cell InteractionCellsCellular ExpansionCellular FunctionCellular GrowthCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular StructuresChemotactic CytokinesConsumptionEndotheliumEnergy ExpenditureEnergy MetabolismEnzyme GeneEnzymesEragrostisEventFOXP3FOXP3 geneFamilyFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryForkhead Box P3Gene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenus HippocampusGoalsGrowthHPGFHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHepatocyte-Stimulating FactorHomeostasisHomologous Chemotactic CytokinesHumanHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL2RIL2RAIL2RA geneIL6 ProteinImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmunesImmunityImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImpairmentInducer CellsInducer T-LymphocytesInfectionInflammationInflammatoryIntercellular JunctionsIntercrinesInterleukin-6Intermediary MetabolismIntracellular Communication and SignalingInvadedInvestigationIslands of Langerhans TransplantationIslands of Pancreas TransplantationIslets of Langerhans GraftingIslets of Langerhans TransplantationJM2KinasesKnock-outKnockoutKnowledgeLAB7LeadLigandsLocationLymphaticLymphatic Endothelial CellsLymphatic cellLymphatic functionLymphocyteLymphocyticLymphotoxinLymphotoxin ALymphotoxin-alphaLymphotoxin-αMGI-2Member 1 TNF SuperfamilyMembraneMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethylationModelingModern ManMolecularMolecular InteractionMolecular Tumor SuppressionMyeloid Differentiation-Inducing ProteinNeoplasm MetastasisPD 1PD-1PD-L1PD1PDL-1Pancreatic Islets TransplantationPathway interactionsPb elementPeptidesPeripheralPermeabilityPhosphotransferase GenePhosphotransferasesPhysiologicPhysiologicalPhysiological HomeostasisPlasmacytoma Growth FactorProductionProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1Promoter RegionsPromotor RegionsPurine Metabolism PathwayPurinesRNA SeqRNA sequencingRNAseqReceptor ProteinRegulationRegulatory T-LymphocyteResearchRoleSCURFINSIS cytokinesSeahorseSecondary NeoplasmSecondary TumorSeminalSignal TransductionSignal Transduction SystemsSignalingSiteStructureSubcellular ProcessSuppressor CellsSuppressor-Effector T-CellsSuppressor-Effector T-LymphocytesT Suppressor CellT-CellsT-LymphocyteT4 CellsT4 LymphocytesTCGFRTNF-bTNF-betaTNF-βTNFSF1TNFβTeffTeff cellThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTimeTissue GrowthTissuesTranscription Factor Proto-OncogeneTranscription factor genesTransphosphorylasesTransplantationTregTumor CellTumor ImmunityTumor Necrosis Factor-BetaTumor Necrosis Factor-βTumor SuppressionVascular Endotheliumallograft rejectionanti-tumor immunityantitumor immunityautologous islet transplantationbiologicbiological signal transductioncancer immunitycancer metastasiscancer microenvironmentcancer vaccinationcell adhesion proteincell growthcell motilitycell typechemoattractant cytokinechemokinedesigndesigningdifferential expressiondifferentially expresseddraining lymph nodeeffector T cellenzyme pathwayextracellularflow cytophotometrygene manipulationgenetic manipulationgenetic promoter elementgenetic promoter sequencegenetically manipulategenetically perturbheavy metal Pbheavy metal leadhost responseimmune system responseimmunoresponsein vivoinhibitorinterferon beta 2islet auto transplantationislet beta cell transplantationislet cell transplantislet cell transplantationislet transplantationknock-downknockdownlymph cellmembrane structuremetabolism measurementmetabolomicsmetabonomicsmigrationneoplastic cellnovelontogenypathwaypharmacologicpreservationpreventpreventingprogrammed cell death 1programmed cell death ligand 1programmed cell death protein 1programmed cell death protein ligand 1programmed death 1promoter sequenceprotein death-ligand 1purine metabolismreceptorregional lymph noderegulatory T-cellsresponsescreeningscreeningssle2social rolesuppressor T lymphocytesystemic lupus erythematosus susceptibility 2thymus derived lymphocytetooltraffickingtranscription factortranscriptional differencestranscriptome sequencingtranscriptomic sequencingtransplanttumortumor cell metastasistumor growthtumor microenvironmenttumor vaccination
Description preview
Foxp3+ regulatory CD4+ T cells (Tregs) induce and maintain tolerance. Tregs co-opt effector or
helper T cell (Th) transcription factors to express similar receptors and migrate to Th resident sites to
suppress immunity. Treg and Th responses are not perfectly aligned, raising questions about how Tregs
are precisely directed to the right location…
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