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Regulatory T Cells and Lymphatic Endothelial Cells: Regulatory Interactions for Migration and Suppression
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 1 Dec 2004Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AdenosineAdoptive TransferAntigen ReceptorsAntigensAreaAutoimmune StatusAutoimmunityAutoregulationB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2B7-H1BCDFBSF-2BSF2Basal Transcription FactorBasal transcription factor genesBindingBloodBlood Reticuloendothelial SystemBlood VesselsBlood leukocyteBody TissuesCCL21CCL21 geneCD106CD106 AntigensCD25CD274CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCKb9CancersCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell surfaceCell-to-Cell InteractionDataDendritic CellsDevelopmentEndothelial CellsEndotheliumEventFOXP3FOXP3 geneForkhead Box P3FundingGatekeepingGeneral Transcription Factor GeneGeneral Transcription FactorsGeographyGoalsHPGFHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHepatocyte-Stimulating FactorHomeostasisHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL2RIL2RAIL2RA geneIL6 ProteinINCAM-110Immune responseImmunityImmunologyInducer CellsInducer T-LymphocytesInducible Cell Adhesion Molecule 110InfectionInflammationInterleukin-6InterruptionIntracellular Communication and SignalingInvestigationIslands of Langerhans TransplantationIslands of Pancreas TransplantationIslets of Langerhans GraftingIslets of Langerhans TransplantationJM2KinasesKineticsLeukocytesLeukocytes Reticuloendothelial SystemLigandsLymphaticLymphatic Endothelial CellsLymphatic EndotheliumLymphatic TissueLymphatic cellLymphocyteLymphocyticLymphoid TissueLymphotoxinLymphotoxin ALymphotoxin-alphaLymphotoxin-αMGC34555MGI-2Malignant NeoplasmsMalignant TumorMarrow leukocyteMember 1 TNF SuperfamilyMolecular InteractionMyeloid Differentiation-Inducing ProteinPD 1PD-1PD-1/PD-L1PD-1/PDL1PD-L1PD1PD1-PD-L1PD1/PD-L1PD1/PDL1PDL-1Pancreatic Islets TransplantationPeripheralPhenotypePhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPlasmacytoma Growth FactorProductionProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1PublicationsReceptor CellReceptor ProteinReceptor SignalingRegulatory T-LymphocyteResolutionRoleSCURFINSCYA21SLCScientific PublicationSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteStimulusStructureSystemT4 CellsT4 LymphocytesTCA4TCGFRTNF-bTNF-betaTNF-βTNFSF1TNFβTherapeuticThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTimeTissuesTranscription Factor Proto-OncogeneTranscription factor genesTransphosphorylasesTransplantationTransplantation ToleranceTregTumor Necrosis Factor-BetaTumor Necrosis Factor-βVCAMVCAM-1VaccinationVascular Cell Adhesion MoleculeVascular Cell Adhesion Molecule-1Vascular EndotheliumVeiled CellsWhite Blood CellsWhite Cellallograft rejectionalloimmunityautologous islet transplantationbiological signal transductionconditioningdevelopmentaldraining lymph nodegatekeeperhost responseimmune system responseimmunogenimmunoresponseinterferon beta 2islet auto transplantationislet beta cell transplantationislet cell transplantislet cell transplantationislet transplantationisoimmunitylymph cellmalignancymigrationneoplasm/cancernovelpathogenpermissivenesspolarized cellprogrammed cell death 1programmed cell death ligand 1programmed cell death protein 1programmed cell death protein ligand 1programmed death 1protein death-ligand 1receptorregional lymph noderegulatory T-cellsresolutionsresponsesle2social rolesystemic lupus erythematosus susceptibility 2traffickingtranscription factortransplantvascularwhite blood cellwhite blood corpuscle
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Project Summary/Abstract
Foxp3+ regulatory CD4+ T cells (Treg) induce and maintain tolerance. Treg also limit the tempo
and strength of normal immune responses to environmental antigens and pathogens. How Treg are regulated
to manifest these functions is incompletely understood. Treg co-opt helper T cell (Th) transcription factors to
express…
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