grant
Regulatory mechanisms for the biogenesis and polymerization of alpha/beta tubulin and their impact on Microtubule Function
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AddressAssayBindingBioassayBiochemicalBiogenesisBiologic ModelsBiologicalBiological AssayBiological ModelsCancersCell BodyCellsCellular MatrixCellular RegulationCellular biologyChaperoneCollaborationsCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmCytoskeletal SystemCytoskeletonDNA mutationDedicationsDefectDevelopmentElectron CryomicroscopyEncephalopathiesEukaryotic CellFluorescence Light MicroscopyFluorescence MicroscopyG-ProteinsGTPGTP-Binding ProteinsGTP-Regulatory ProteinsGeneralized GrowthGenesGenetic ChangeGenetic defectGenetic mutationGrowthGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsGuanosine TriphosphateHereditaryHereditary DiseaseHumanHydrolysisImageImpairmentIn VitroInborn Genetic DiseasesInheritedInherited disorderLinkMalignant NeoplasmsMalignant TumorMediatingMethodsMicro-tubuleMicrotubule PolymerizationMicrotubulesModel SystemModelingModern ManMolecularMolecular ChaperonesMolecular InteractionMutationNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersOrigin of LifePathway interactionsPatientsPolymersPropertyProteinsPublic HealthQuality ControlRegulationResearchResolutionRoleShapesStructureTissue GrowthTranslationsTubulinTumor CellYeastsagyriabeta Tubulinbiologiccell biologycell growth regulationcofactorcryo-EMcryoEMcryogenic electron microscopydevelopmentaldevelopmental diseasedevelopmental disordergenome mutationgiant axonal neuropathyhereditary disorderheritable disorderimagingin vivoin vivo Modelinborn errorinherited diseasesinherited genetic diseaseinherited genetic disorderintracellular skeletonlissencephalylissencephaly pachygyriamalignancymigrationmonomermutantneoplasm/cancerneoplastic cellneurological diseasenovelontogenyoverexpressoverexpressionpathwaypolymerpolymericpolymerizationreconstitutereconstitutionrecruitresolutionssocial rolestemtraffickingtranslationtumortumor growthβ-Tubulin
Description preview
Project Summary
The dynamic microtubule cytoskeleton mediates intracellular organization, generates forces for
dividing or migrating eukaryotic cells, and forms tracks for intracellular trafficking. The fundamental
properties of microtubules, including polarized growth and “dynamic instability” stem directly from the
activities of their building…
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