grant
Regulation of viral-bacterial co-infections by immunometabolism
NIHUS FederalResearch GrantFY2025AccountingActive OxygenAcuteAirway examinationAnti-Bacterial AgentsAnti-viral ResponseAntibiotic ResistanceAntibiotic TherapyAntibiotic TreatmentArbitratingArbitrationBacterial InfectionsBioavailabilityBiogenesisBiologic ModelsBiological AvailabilityBiological ModelsBronchiectasisCF airwayCF airway epitheliaCF lung diseaseCF patientsCOPDCancersCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell ProtectionCell SignalingCellular FunctionCellular PhysiologyCellular ProcessCharacteristicsChronicChronic DiseaseChronic IllnessChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseCystic FibrosisCytoprotectionDataDevelopmentDiseaseDisorderDysfunctionEnvironmentEpithelial CellsEpitheliumFe elementFosteringFunctional disorderGeneralized GrowthGenesGoalsGrowthHIF 1 alphaHIF-1alphaHIF1-AlphaHIF1AHIF1A geneHIF1αHexose Monophosphate ShuntHost FactorHost Factor ProteinHumanIFNImmuneImmune responseImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIn VitroInfectionInfluenza AInfluenza A virusInfluenza Viruses Type AInfluenzavirus AIntegration Host FactorsInterferonsIntracellular Communication and SignalingIronLong-term infectionLungLung Respiratory SystemLung damageMOP1MacrophageMalignant NeoplasmsMalignant TumorMediatingMetabolicMiceMice MammalsMicrobial BiofilmsMicrobial PhysiologyModel SystemModelingModern ManMolecularMorbidityMorbidity - disease rateMucociliary ClearanceMucociliary TransportMucosaMucosal TissueMucous MembraneMucoviscidosisMurineMusMφOrangesOrigin of LifeOrthomyxovirus Type AOxidantsOxidative PhosphorylationOxidative Phosphorylation PathwayOxidative StressOxidative Stress InductionOxidizing AgentsOxygen RadicalsP aeruginosaP. aeruginosaP. aeruginosa infectionPathogenesisPathway interactionsPentose Phosphate PathwayPentose Phosphate ShuntPentose ShuntPentosephosphate PathwayPentosephosphate ShuntPersonsPhenotypePhysiologic AvailabilityPhysiopathologyPro-OxidantsPropertyPseudomonas aeruginosaPseudomonas aeruginosa infectionPseudomonas pyocyaneaPulmonary Body SystemPulmonary Cystic FibrosisPulmonary Organ SystemRSV infectionReactive Oxygen SpeciesRegulationReportingResearchResistance to antibioticsResistant to antibioticsRespiratory EpitheliumRespiratory Syncytial Virus InfectionsRespiratory SystemRespiratory TractsRespiratory infectious agentRespiratory syncytial virusRespiratory tract pathogenRespiratory tract structureRoleSeasonsSignal InductionSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeStructure of respiratory epitheliumSubcellular ProcessSurfaceTestingTimeTissue GrowthType A InfluenzaViralViral ActivityViral DiseasesViral FunctionViral PhysiologyViral Respiratory Tract InfectionVirusVirus DiseasesWorkaerobic glycolysisairway epitheliumanti-bacterialanti-microbialantibiotic drug resistanceantibiotic resistantantimicrobialbacteria infectionbacterial diseasebacterial disease treatmentbacterial infectious disease treatmentbiofilmbiofilm communitybiological signal transductionbuild resiliencebuild resiliencycell typechronic disorderchronic infectionchronic obstructive pulmonary disorderco-infectioncoinfectioncystic fibrosis airwaycystic fibrosis airway epitheliacystic fibrosis lungcystic fibrosis lung diseasecystic fibrosis patientscytoprotectivedesigndesigningdevelop resiliencedevelop resiliencydevelopmentalelectron acceptorenhance resilienceenhance resiliencyfacilitate resiliencehost responseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprove resilienceimprove resiliencyimprovedin vivoincrease resilienceincrease resiliencyindividuals with CFindividuals with cystic fibrosisinfected with P. aeruginosainfected with Pseudomonas aeruginosalung injurymalignancymetabolic profilemixed species biofilmmortalitymulti-microorganism biofilmmultispecies biofilmneoplasm/cancernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetontogenyopportunistic pathogenpathogenpathogenic viruspathophysiologypathwaypatients with CFpatients with cystic fibrosispersistent infectionpolymicrobial biofilmpreservationpreventpreventingprogramspromote resiliencepromote resiliencypulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryrecruitresilience developmentrespiratory examinationrespiratory infection virusrespiratory pathogenrespiratory tract epitheliumrespiratory virusresponsesocial rolesynergismviral infectionviral pathogenviral respiratory infectionvirus infectionvirus pathogenvirus-induced disease
Description preview
SUMMARY/ABSTRACT
Pseudomonas aeruginosa is a major respiratory pathogen in the pathogenesis of Cystic Fibrosis (CF) and the
ineffective immune response to this pathogen is thought to cause the majority of the lung damage characteristic
of this disease. In the later stages of CF, P. aeruginosa reside in biofilm communities in the lung, accounting…
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