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Regulation of Pathologic Inflammasome Responses to SARS-CoV-2
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 23 May 2024Deadline 18 Jun 2025 ⚠️
NIHUS FederalResearch GrantFY2025(TNF)-α2019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV variant2019-nCoV variant forms2019-nCoV variant strainsARDSAcute Lung InjuryAcute Pulmonary InjuryAcute Respiratory DistressAcute Respiratory Distress SyndromeAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAdvisory CommitteesApoptosis-Related Cysteine Protease Caspase 1B cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Beta Proprotein Interleukin 1BleedingBlood leukocyteBody TissuesBody WeightBystander EffectCASP-1CASP1CASP1 geneCD126 AntigensCD126 ReceptorCOVID infected patientCOVID patientCOVID positive patientCOVID testCOVID testsCOVID-19COVID-19 antibodyCOVID-19 associated deathCOVID-19 associated fatalityCOVID-19 associated mortalityCOVID-19 deathCOVID-19 fatalityCOVID-19 induced deathCOVID-19 induced fatalityCOVID-19 induced mortalityCOVID-19 infected patientCOVID-19 infectionCOVID-19 mortalityCOVID-19 patientCOVID-19 positive patientCOVID-19 related deathCOVID-19 related fatalityCOVID-19 related mortalityCOVID-19 testCOVID-19 testsCOVID-19 variantCOVID-19 variant formsCOVID-19 variant strainsCOVID-19 virusCOVID-19 virus infectionCOVID19 associated deathCOVID19 associated fatalityCOVID19 associated mortalityCOVID19 deathCOVID19 fatalityCOVID19 induced deathCOVID19 induced fatalityCOVID19 induced mortalityCOVID19 infectionCOVID19 mortalityCOVID19 patientCOVID19 positive patientCOVID19 related deathCOVID19 related fatalityCOVID19 related mortalityCOVID19 virusCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCV-19CachectinCas nuclease technologyCaspase-1Caspase-1 GeneCell BodyCell CommunicationCell Communication and SignalingCell Culture TechniquesCell DeathCell Death InductionCell InteractionCell SignalingCell secretionCell-to-Cell InteractionCellsCellular SecretionClinical TrialsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCo-cultureCoV-2CoV2CocultivationCocultureCoculture TechniquesCollaborationsCommunitiesCoronavirus Infectious Disease 2019CuesDNADNA Molecular BiologyDa Nang LungDataDeoxyribonucleic AcidDiseaseDisorderEnvelope ProteinEpithelial CellsEpitheliumExogenous FactorsFacultyGene DeletionGenesGoalsHPGFHealthHemorrhageHepatocyte-Stimulating FactorHumanHybridoma Growth FactorICE ProteaseIFN-beta 2IFNB2IL-1IL-1 betaIL-1 beta ConvertaseIL-1 beta-Converting EnzymeIL-1 βIL-1-bIL-1BCIL-1b Converting EnzymeIL-1raIL-1βIL-6IL-6 ReceptorsIL1IL1 febrile inhibitorIL1-BetaIL1-βIL1B ProteinIL1B-ConvertaseIL1BCIL1BCEIL1F2IL1RNIL1βIL6 ProteinIL6 ReceptorsImmuneImmunesIn VitroIn vivo analysisInfectionInfection ControlInflammasomeInflammationInflammation MediatorsInflammatoryInflammatory ResponseInnate Immune ResponseInterleukin 1-B Converting EnzymeInterleukin 1-Beta ConvertaseInterleukin 1betaInterleukin 6 ReceptorInterleukin IInterleukin-1Interleukin-1 Beta Converting EnzymeInterleukin-1 Converting EnzymeInterleukin-1 Receptor AntagonistInterleukin-1 betaInterleukin-1βInterleukin-6Intracellular Communication and SignalingInvestigatorsKinasesLeukocytesLeukocytes Reticuloendothelial SystemLigandsLinkLungLung Respiratory SystemLung damageLymphocyte-Stimulating HormoneLyticMGI-2Macrophage Cell FactorMacrophage-Derived TNFMarrow leukocyteMediatingMeta-AnalysisMiceMice MammalsModelingModern ManMolecularMolecular BiologyMolecular TargetMonocyte-Derived TNFMurineMusMyelogenousMyeloidMyeloid CellsMyeloid Differentiation-Inducing ProteinNamesOutcomePathologicPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPattern recognition receptorPhosphorylationPhosphotransferase GenePhosphotransferasesPlasmacytoma Growth FactorPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPreinterleukin 1 BetaProductionProtein ModificationProtein PhosphorylationProteinsReceptor ProteinReceptor SignalingRegulationResearchResearch PersonnelResearchersRespiratory EpitheliumRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 antibodySARS-CoV-2 associated deathSARS-CoV-2 associated fatalitySARS-CoV-2 associated mortalitySARS-CoV-2 deathSARS-CoV-2 fatalitySARS-CoV-2 induced deathSARS-CoV-2 induced fatalitySARS-CoV-2 induced mortalitySARS-CoV-2 infected patientSARS-CoV-2 infectionSARS-CoV-2 mortalitySARS-CoV-2 patientSARS-CoV-2 positive patientSARS-CoV-2 related deathSARS-CoV-2 related fatalitySARS-CoV-2 related mortalitySARS-CoV-2 testSARS-CoV-2 testsSARS-CoV-2 variantSARS-CoV-2 variant formsSARS-CoV-2 variant strainsSARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SamplingSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome related corona virus 2SeveritiesShock LungSightSignal TransductionSignal Transduction SystemsSignalingSourceStiff lungStimulusStructure of respiratory epitheliumSystemT Helper FactorTLR proteinTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTask ForcesTestingTherapeuticTissuesToll-Like Receptor Family GeneToll-like receptorsTransphosphorylasesTumor Necrosis FactorTumor Necrosis Factor-alphaUniversitiesViral DiseasesVirionVirusVirus DiseasesVirus ParticleVisionWhite Blood CellsWhite CellWorkWuhan coronavirusadapter proteinadvisory teamafter COVID-19 infectionafter SARS-CoV-2 infectionafter SARS-CoV2 infectionafter infection by SARS-CoV-2after severe acute respiratory distress syndrome CoV-2 infectionairway epitheliumanakinraantibody against COVID-19antibody against SARS-CoV-2antibody against coronavirus disease 2019antibody against severe acute respiratory syndrome coronavirus 2antibody to COVID-19antibody to SARS-CoV-2antibody to coronavirus disease 2019antibody to severe acute respiratory syndrome coronavirus 2biological signal transductionbiomarker identificationblood losscell culturecell culturescell typecoronavirus disease 2019coronavirus disease 2019 antibodycoronavirus disease 2019 associated deathcoronavirus disease 2019 associated fatalitycoronavirus disease 2019 associated mortalitycoronavirus disease 2019 deathcoronavirus disease 2019 fatalitycoronavirus disease 2019 induced deathcoronavirus disease 2019 induced fatalitycoronavirus disease 2019 induced mortalitycoronavirus disease 2019 infected patientcoronavirus disease 2019 infectioncoronavirus disease 2019 mortalitycoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 related deathcoronavirus disease 2019 related fatalitycoronavirus disease 2019 related mortalitycoronavirus disease 2019 testcoronavirus disease 2019 testscoronavirus disease 2019 variantcoronavirus disease 2019 variant formscoronavirus disease 2019 variant strainscoronavirus disease 2019 viruscoronavirus disease infected patientcoronavirus disease patientcoronavirus disease positive patientcoronavirus disease testcoronavirus disease testscoronavirus disease-19coronavirus disease-19 mortalitycoronavirus disease-19 patientcoronavirus disease-19 viruscoronavirus infectious disease-19coronavirus patientcoronavirus testcoronavirus testscytokinecytokine release syndromecytokine stormdeath due to COVID-19death due to COVID19death due to SARS-CoV-2death due to coronavirus disease 2019death due to severe acute respiratory syndrome coronavirus 2death in COVIDdeath in COVID-19death in SARS-CoV-2death in coronavirus diseasedeath in coronavirus disease 2019death in severe acute respiratory syndrome coronavirus 2designdesigningenv Antigensenv Gene Productsenv Polyproteinsenv Proteinfatality due to COVID-19fatality due to COVID19fatality due to SARS-CoV-2fatality due to coronavirus disease 2019fatality due to severe acute respiratory syndrome coronavirus 2following COVID-19 infectionfollowing SARS-CoV-2 infectionfollowing SARS-CoV2 infectionfollowing infection by SARS-CoV-2following severe acute respiratory distress syndrome CoV-2 infectiongene deletion mutationhCoV19identification of biomarkersidentification of new biomarkersin vivoin vivo evaluationin vivo testinginfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2inflammatory mediatorinsightinterferon beta 2interleukin 1 receptor antagonist proteinlife-threatening COVIDlife-threatening COVID-19life-threatening SARS-CoV-2life-threatening coronavirus diseaselife-threatening coronavirus disease 2019life-threatening severe acute respiratory syndrome coronavirus 2lung injurylymphocyte activating factormarker identificationmembermortality due to COVID-19mortality due to COVID19mortality due to SARS-CoV-2mortality due to coronavirus disease 2019mortality due to severe acute respiratory syndrome coronavirus 2mouse modelmultiomicsmultiple omicsmurine modelnCoV2namenamednamingnecrocytosispanomicspathogenpathogenic viruspathwaypatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient oriented outcomespatient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2post SARS-CoV-2 infectionprevious COVID-19 infectionprevious SARS-CoV-2 infectionprevious SARS-CoV2 infectionprevious severe acute respiratory distress syndrome CoV-2 infectionprior COVID-19 infectionprior SARS-CoV-2 infectionprior SARS-CoV2 infectionprior severe acute respiratory distress syndrome CoV-2 infectionprogramsprotein complexpulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryreceptorrespiratory tract epitheliumresponsescRNA sequencingscRNA-seqserious COVIDserious COVID-19serious SARS-CoV-2serious coronavirus diseaseserious coronavirus disease 2019serious severe acute respiratory syndrome coronavirus 2severe COVIDsevere COVID-19severe COVID19severe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 antibodysevere acute respiratory syndrome coronavirus 2 associated deathsevere acute respiratory syndrome coronavirus 2 associated fatalitysevere acute respiratory syndrome coronavirus 2 associated mortalitysevere acute respiratory syndrome coronavirus 2 deathsevere acute respiratory syndrome coronavirus 2 fatalitysevere acute respiratory syndrome coronavirus 2 induced deathsevere acute respiratory syndrome coronavirus 2 induced fatalitysevere acute respiratory syndrome coronavirus 2 induced mortalitysevere acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 mortalitysevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsevere acute respiratory syndrome coronavirus 2 related deathsevere acute respiratory syndrome coronavirus 2 related fatalitysevere acute respiratory syndrome coronavirus 2 related mortalitysevere acute respiratory syndrome coronavirus 2 testsevere acute respiratory syndrome coronavirus 2 testssevere acute respiratory syndrome coronavirus 2 variantsevere acute respiratory syndrome coronavirus 2 variant formssevere acute respiratory syndrome coronavirus 2 variant strainssevere coronavirus diseasesevere coronavirus disease 19severe coronavirus disease 2019severe severe acute respiratory syndrome coronavirus 2single cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolesuccesstest for COVIDtherapeutic targeturine IL-1 inhibitorurine interleukin 1 inhibitorurine-derived IL1 inhibitorviral infectionviral pathogenvirus infectionvirus pathogenvirus-induced diseasevisual functionwet lungwhite blood cellwhite blood corpuscle
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Project Summary
Acute respiratory distress syndrome (ARDS) causes COVID-19 fatalities and is linked to uncontrolled
release of pro-inflammatory cytokines, including interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF).
Blockade of IL-1/IL-6 receptor signaling has shown success in treating severe COVID-19, but the molecular cues
initiating…
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