grant
Regulation of Oxytocin Receptor Signaling in Neurons
Organization UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTRLocation OKLAHOMA CITY, UNITED STATESPosted 20 Jul 2022Deadline 30 Apr 2027
NIHUS FederalResearch GrantFY2026ASDAgonistAnimal BehaviorArrestinsAutismAutistic DisorderBehavioralBindingBrainBrain DiseasesBrain DisordersBrain Nervous SystemBrain regionC-terminalCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell Communication and SignalingCell SignalingClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCommunicationComplexConnector NeuronCouplingDataDiseaseDisorderDrugsEarly Infantile AutismElectrophysiologyElectrophysiology (science)EncephalonEncephalon DiseasesEndocrine Gland SecretionFoundationsFutureG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG Protein-Coupled Receptor Kinase FamilyG Protein-Coupled Receptor SignalingG protein coupled receptor kinaseG-Protein-Coupled ReceptorsG-ProteinsGPCRGPCR SignalingGRKGTP-Binding ProteinsGTP-Regulatory ProteinsGenerationsGenetics-MutagenesisGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHormonesImpairmentIn VitroInfantile AutismIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersIntranasal AdministrationIntranasal Drug AdministrationInvestigationIsoformsKI miceKanner's SyndromeKnock-in MouseKnowledgeLabelLactationMediatingMedicationMental disordersMental health disordersMiceMice MammalsModalityMolecularMolecular InteractionMurineMusMutagenesisMutagenesis Molecular BiologyMutateNerve CellsNerve UnitNeural CellNeurocyteNeuromodulatorNeuronsNeurophysiology / ElectrophysiologyOcytocinOxytocinOxytocin ReceptorPalmitic Acylation SitePalmitoylation SitePharmaceutical PreparationsPhosphorylationPhosphorylation SitePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPreventionProcessPropertyProtein IsoformsProtein ModificationProtein PhosphorylationProteinsProteomicsPsychiatric DiseasePsychiatric DisorderReceptor ActivationReceptor ProteinReceptor SignalingRecombinant OxytocinRegulationRetinal S-AntigenRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSliceSocial BehaviorSocial ControlsStructureSystemTailTechniquesTestingTimeVirusWorkanxiety-related behaviorautism attributesautism indicatorautism spectral disorderautism spectrum disorderautism spectrum disorder featuresautism spectrum disorder indicatorautism spectrum disorder symptomsautism symptomologyautism symptomsautism-like symptomsautism-related attributesautistic featuresautistic spectrum disorderautistic symptomsautistic traitsautistic-like symptomsbiological signal transductiondebilitating symptomdecay accelerationdesensitizationdrug/agentelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsin vivoinsightknock-downknockdownknockin micelactatinglactationalmental illnessmutantneuronalneuronal circuitneuronal circuitryneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatrynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpalmitoylationpreventpreventingprotein complexpsychiatric illnesspsychological disorderreceptorreceptor internalizationrecruitresponsesocialsocial cognitionsocial defectssocial deficitssocial disorderssocial dysfunctionsocial rolesociobehaviorsociobehavioraltherapeutic agent developmenttherapeutic development
Description preview
PROJECT SUMMARY/ABSTRACT
Social deficits are a prominent feature of autism spectrum disorder and many other
neuropsychiatric diseases. Since there are currently no drugs available to treat these debilitating
symptoms, it is critical to decipher the neuronal mechanisms underlying social behavior and their
impairments in mental illnesses. Oxytocin,…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click