grant
Regulation of Osteoclastogenesis and Inflammatory Osteolysis
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025(IFN) α(IFN)-α(IFN)α(TNF)-αAPF-1ATP-Dependent Proteolysis Factor 1AblationAccelerationAlferonAutophagocytosisAutoregulationBindingBlood SerumBone ResorptionBone remodelingCachectinCalibrationCell BodyCell Communication and SignalingCell SignalingCell secretionCellsCellular SecretionDataEndogenous Interferon BetaEnzyme GeneEnzymesEventExtracellular SpaceFamilyFeedbackFibroblast InterferonGenesGoalsHMG-20High Mobility Protein 20HomeostasisIFNIFN AlphaIFN αIFN-αIFN-βIFNaIFNbIFNαImmunoglobulin Enhancer-Binding ProteinIn VitroInflammatoryInjectionsIntercellular SpaceInterferon Alfa-n3Interferon Type IInterferon-αInterferon-βInterferonsIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceLeukocyte InterferonLigandsLigaseLigase GeneLymphoblast InterferonLymphoblastoid InterferonMacrophage-Derived TNFMediatingMetabolicMiceMice MammalsModalityMolecularMolecular InteractionMonocyte-Derived TNFMurineMusMyelogenousMyeloidMyeloid CellsNF-kBNF-kappa BNF-kappaBNFKBNatural Interferon BetaNatural human interferon betaNuclear Factor kappa BNuclear Transcription Factor NF-kBNull MouseOCIF proteinOPG proteinOsteoclastic Bone LossOsteoclastsOsteolysisOsteopeniaPathologicPathway interactionsPhysiologicPhysiologicalPhysiological HomeostasisPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProductionProtein ModificationProteinsProteomicsRANK proteinReceptor ProteinReceptor SignalingRegulationRoleSecretory GranulesSecretory VesiclesSerumSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSiteStimulator of Interferon GenesSynthetasesTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFRSF11A gene productTNFRSF11B gene productTNFαTestingTranscription Factor NF-kBTumor Necrosis FactorTumor Necrosis Factor Receptor Superfamily Member 11BTumor Necrosis Factor-alphaTumor necrosis factor receptor 11bUbiquitinVirusautophagybiological signal transductionbone losscGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcombatcyclic GMP-AMP synthase/STINGcytokinein vivokappa B Enhancer Binding Proteinmemberneutralizing antibodynovelnuclear factor kappa betaopg gene productosteoclast progenitorosteoclastogenesisosteoclastogenesis inhibitory factorosteoprotegerinoverexpressoverexpressionparacrinepathwayprogenitor cell differentiationprogenitor differentiationreceptorreceptor activator of NF-kappaBresponsesmall moleculesocial rolestem and progenitor differentiationstem cell differentiation
Get Agency plan to apply$29.99/mo · 7-day free trial · pipeline · alerts
or
— or —Get email alerts for similar roles
Description preview
Project Summary/Abstract
Osteoclasts (OCs), the bone resorbing cells, arise from myeloid OC progenitors (OCPs) and are critical
for bone remodeling and homeostasis. OC differentiation and activity are tightly regulated by intrinsic negative
feedback loops (autoregulatory) and by paracrine factors secreted by other cells, most notably…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click