grant
Regulation of nociceptor excitability by macrophage migration inhibitory factor (MIF) as a therapeutic strategy for chronic pain treatment after spinal cord injury
Organization UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTONLocation HOUSTON, UNITED STATESPosted 15 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-Kinase21+ years oldAction PotentialsAcuteAdultAdult HumanAffectAffectiveAfferent NeuronsAnalgesia TestsAssayAutomobile DrivingBAXBAX geneBCL2-Associated X Protein GeneBCL2L4BehavioralBioassayBiological AssayBloodBlood PlasmaBlood Reticuloendothelial SystemC-X-C Chemokine Receptor Type 4CD184 AntigenCDw128bCDw128b AntigensCMKAR2CXC Chemokine Receptor 2CXC-R4CXCR-4CXCR2CXCR2 ProteinCXCR2 ReceptorsCXCR4CXCR4 ReceptorsCXCR4 geneCell BodyCell Communication and SignalingCell SignalingCellsCerebrospinal FluidChemokine (C-X-C Motif) Receptor 4Chemokine (C-X-C) Receptor 2Chemokine, CXC Motif, Receptor 4ChestChronicClinicalClinical TrialsCommon Rat StrainsComplementComplement ProteinsConflictConflict (Psychology)D2S201EDataDissociationDorsal Root GangliaEconomic BurdenElectrophysiologyElectrophysiology (science)Endocrine Gland SecretionExhibitsExposure toFB22FusinGRO/MGSA ReceptorGenetic ModelsGenetic studyHEAL InitiativeHM89HSY3RRHelping End Addiction Long-termHelping to End Addiction Long-termHigh Affinity Interleukin 8 Receptor Type BHormonesHumanHyperactivityHypersensitivityIL-8RBIL-8RbetaIL8 Receptor Type 2IL8R2IL8RBIL8RB geneIn VitroIndividualInflammatoryInjectionsInjuryInnate Immune ResponseInterleukin 8 Receptor BetaInterleukin 8 Receptor Type 2Interleukin-8 Receptor Type BInterleukin-8 Receptors BInterleukin-8B ReceptorIntracellular Communication and SignalingKnock-outKnockoutLAP3LCR1LESTRLESTR ReceptorLPS-Associated Protein 3LesionLeukocyte-Derived Seven-Transmembrane Domain ReceptorLipopolysaccharide-Associated Protein 3LocationLong-term painLymphatic cellLymphocyteLymphocyticMacrophageMacrophage Migration Inhibition FactorsMacrophage Migration Inhibitory FactorMaintenanceMechanicsMediatingMediatorMembrane PotentialsMiceMice MammalsMigration Inhibition FactorMigration Inhibitory FactorModelingModern ManMolecularMurineMusMφNPY3RNPYRNPYRLNPYY3RNational Institutes of HealthNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuropeptide Y Receptor Y3Neurophysiology / ElectrophysiologyNociceptionNociception TestsNociceptorsOpiatesOpioidOrgan DonorPI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePainPain AssessmentPain MeasurementPain measurePainfulPathway interactionsPeripheral nerve injuryPersistent painPersonsPhosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePhysiologicPhysiologicalPlasmaPlasma SerumPre-Clinical ModelPreclinical ModelsPtdIns 3-KinaseQOLQuality of lifeRatRats MammalsRattusReceptor ProteinReflexReflex actionRefractoryRegulationReportingResearchResistanceResting PotentialsReticuloendothelial System, Serum, PlasmaRodentRodent ModelRodentiaRodents MammalsRoleSCI PatientsSDF-1 ReceptorSDF1/PBSF Receptor CXCR4SensorySensory NeuronsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpinalSpinal Cord TraumaSpinal GangliaSpinal TraumaSpinal cord injuredSpinal cord injurySpinal cord injury patientsSpleen Seven-Transmembrane-Segment ReceptorStromal Cell-Derived Factor 1 ReceptorTestingTetracyclinesTherapeuticTherapeutic HormoneThoraceThoracicThoraxTransmembrane PotentialsTraumatic MyelopathyTraumatic injuryTreatment FactorType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseUnited States National Institutes of HealthVascular PermeabilitiesVascularizationWorkadulthoodantagonismantagonistarylpyruvate keto-enol tautomerasebehavior testbehavioral testbiological signal transductioncell typecerebral spinal fluidchronic neuropathic painchronic painchronic pain controlchronic pain interventionchronic pain managementchronic pain therapychronic pain treatmentclinical relevanceclinically relevantcomplementationconditioned place preferenceconstant paincytokinedefined contributiondorsal root gangliondrivingelectrophysiologicalgenetic predictorsinflammatory paininhibitorinjuriesinnovateinnovationinnovativeinterdisciplinary approachknock-downknockdownlasting painlymph cellmechanicmechanicalmouse geneticsmultidisciplinarymultidisciplinary approachneuronalneuropathic painnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynociceptivenociceptive neuronsnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targeton-going painongoing painp-hydroxyphenylpyruvate tautomerasepain assaypain behaviorpain reductionpain-sensing neuronspain-sensing sensory neuronspain-sensing somatosensory neuronspainful neuropathypathwayperipheral nerve crush injuriespharmacologicphenylpyruvate tautomeraseplace conditioningreceptorreduce painrelease factorresistantside effectsocial rolespinal cord injury painspinal fluidtherapeutic targettranslational opportunitiestranslational potentialtreat chronic pain
Description preview
Project summary
Affecting over half of people living with spinal cord injury (SCI), chronic neuropathic pain can have a disastrous
impact on quality of life. Despite recent advances in understanding neuropathic pain, its mechanisms remain
elusive and it is still largely resistant to available treatments, including opioids. Increasing evidence…
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