grant
Regulation of Mucosal Lymphocytes
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Sept 1998Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AddressAdhesion MoleculeAffinityAlternate SplicingAlternative RNA SplicingAlternative SplicingAnimal ModelAnimal Models and Related StudiesApicalB breveB. breveBacillus casei gBacillus gBacteriaBacterial TranslocationBetabacterium breveBindingBinding SitesBiophysicsCD66a antigenCD66e AntigenCEACAM1Carcinoembryonic AntigenCarcinoembryonic Antigen-Related Cell Adhesion Molecule 5CatalogsCell Adhesion Molecule GeneCell Adhesion MoleculesCell Communication and SignalingCell SignalingClosure by LigationColitisCombining SiteCoupledCytoplasmic DomainCytoplasmic TailDSS colitisDSS modelDSS mouse modelDSS-induced acute colitisDSS-induced colitisDataDefense MechanismsDiseaseDisorderDistalDown-RegulationEpithelial CellsEpitheliumExhibitsExposure toFaceFamilyGenerationsGoalsHealthHomodimerizationHumanHuman CharacteristicsHuman NatureImmuneImmune GlobulinsImmunesImmunoglobulinsIn VitroInfectionInflammatory Bowel DiseasesInflammatory Bowel DisorderIntegral Membrane ProteinIntestinalIntestinesIntracellular Communication and SignalingIntrinsic Membrane ProteinInvadedIsoformsL breveL brevisL monocytogenesL. breveL. brevisL. monocytogenesLactobacillus brevisLactobacterium breveLigand BindingLigandsLigationLightLinkListeria monocytogenesLymphatic cellLymphocyteLymphocyticMeconium Antigen 100MediatingMembraneMiceMice MammalsMicrobeMissionModern ManMolecular InteractionMucosaMucosal TissueMucous MembraneMurineMusMyeloid CellsN DomainNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesOutcomePhotoradiationPlayPopulationPredispositionProcessProductionPropertyProtein IsoformsPublic HealthReactive SiteRegulationResearchResearch ProposalsRoleSignal TransductionSignal Transduction SystemsSignalingSiteSourceSurfaceSusceptibilitySystemTestingTherapeuticTimeTransmembrane ProteinTransmembrane Protein GeneVariantVariationanti-microbial peptidebiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencesbowelbowel inflammationcarcinoembryonal antigencatalogcell adhesion proteincell typecolitis-induced dysbiosiscommensal floracommensal microbescommensal microbiotacommensal microfloraconditional knock-outconditional knockoutdextran sulfate sodium colitisdextran sulfate sodium induced colitisdextran sulfate sodium modeldextran sulfate sodium mouse modelenteral pathogenenteric pathogenenteropathogenfacesfacialgain of functiongut inflammationhumanized micehumanized mousein vivoinflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinsightintestinal autoinflammationintestinal epitheliumintestinal inflammationintestinal pathogenintestine pathogenknock-out animalknockout animallymph cellmembermembrane structuremicrobe pathogenmicrobialmicrobial pathogenmodel of animalmouse modelmurine modelmutantnative protein drugnovelpathogenic microbepharmaceutical proteinpharmacologicprotein drug agentprotein-based drugpsychological defense mechanismresponsesensorsocial roletherapeutic protein
Description preview
PROJECT SUMMARY/ABSTRACT
CEACAM1 is a single-pass type I transmembrane protein and the primordial member of the carcinoembryonic
antigen (CEA) family of immunoglobulin molecules that is expressed on the apical and basolateral surfaces of
intestinal epithelial cells (IEC) and on a wide range of immune cell types. However, its functions on…
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