grant

Regulation of mitochondrial morphology and functional versatility

Organization NEW YORK UNIVERSITYLocation NEW YORK, UNITED STATESPosted 1 Aug 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025Ampullary CrestApoptosisApoptosis PathwayArchitectureBiochemical ReactionBioenergeticsCancersCardiolipinsCardiovascular DiseasesCell BodyCell FunctionCell PhysiologyCell ProcessCell divisionCellsCellular FunctionCellular PhysiologyCellular ProcessCharacteristicsChromosomal, Gene, or Protein AbnormalityCommunicationComplexCrista ampullarisCytogenetic or Molecular Genetic AbnormalityDegenerative Neurologic DisordersDevelopmentDiseaseDisorderEngineering / ArchitectureEnzymatic ReactionEukaryotic CellGTP PhosphohydrolasesGTPasesGenetic AbnormalityGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHumanImpairmentIntermediary MetabolismKIAA0567KnowledgeLinkLipidsMaintenanceMalignant NeoplasmsMalignant TumorMembraneMetabolic ProcessesMetabolismMitochondriaMitochondrial DNAMitochondrial Dynamin-Like 120-KD ProteinMitochondrial ProteinsModern ManMolecularMolecular AbnormalityMorphogenesisMorphologyMuscleMuscle TissueNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuronsOPA1OPA1 geneObesityOrganellesOrganism-Level ProcessOrganismal ProcessOxidative PhosphorylationOxidative Phosphorylation PathwayPathologyPhysiologic ProcessesPhysiological ProcessesPlayProbabilityProcessProgrammed Cell DeathProtein DynamicsProteinsRegulationReticulumRoleShapesSiteSpatial DistributionStructureSubcellular Processadiposityage associatedage associated diseaseage associated disorderage associated impairmentage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage linkedage relatedage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentcardiovascular disordercatalystcorpulencecrista ampullacristaedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentalenvironmental changeguanosinetriphosphatasemalignancymembrane structuremigrationmitochondrialmitochondrial dysfunctionmolecular aberrationsmorphogenetic processmtDNAmuscularneoplasm/cancerneurodegenerative illnessneuronalnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachrespiratorysocial rolespatial and temporalspatial temporalspatiotemporalsuccess
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PROJECT SUMMARY
Eukaryotic cells sequester critical biochemical reactions into discrete membranous compartments, whereby

membrane dynamics driven by protein catalysts facilitate differentiation, communication, and spatial organization

of intracellular compartments. Within a cell, mitochondria are mainly organized into highly interconnected…

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