grant
Regulation of inflammation by the ubiquitin proteasome pathway
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 1 Feb 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAPF-1ATP-Dependent Proteolysis Factor 1AffectAmericanAnimal ModelAnimal Models and Related StudiesAtrophic ArthritisAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBM Stem CellBM derived progenitorBM progenitorBM- derived Stem CellsBiochemistryBiological ChemistryBloodBlood DiseasesBlood Precursor CellBlood Reticuloendothelial SystemBone MarrowBone Marrow Reticuloendothelial SystemBone Marrow Stem CellBone Marrow progenitorBrachydanio rerioCell BodyCell Communication and SignalingCell LineCell SignalingCell modelCellLineCellsCellular modelChemicalsClinicalClonal ExpansionCranial ArteritisCultured CellsCytoplasmDNA mutationDanio rerioDisadvantagedDiseaseDisorderEnzyme ActivationEnzyme GeneEnzymesExhibitsGenetic ChangeGenetic defectGenetic mutationGiant Cell ArteritisGoalsHMG-20Hematologic DiseasesHematological DiseaseHematological DisorderHematopoiesisHematopoieticHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic stem cellsHigh Mobility Protein 20Horton DiseaseHorton Giant Cell ArteritisHorton's Giant Cell AortitisImmuneImmunesIndividualInflammationInflammatoryIntracellular Communication and SignalingIsoformsKnock-inLeadLinkLoxP-flanked alleleLymphatic cellLymphocyteLymphocyticLymphoid CellMacropainMacroxyproteinaseMediatingMiceMice MammalsModelingMolecularMorbidityMorbidity - disease rateMulticatalytic ProteinaseMurineMusMusculoskeletal Pain DisorderMutationMyelogenousMyeloidMyeloid CellsMyeloid ProgenitorMyeloid Progenitor CellsMyeloid Stem CellsPathogenesisPathogenicityPathway interactionsPatientsPb elementPhenotypePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProgenitor CellsProsomeProteasomeProteasome Endopeptidase ComplexProtein IsoformsProtein ModificationProteinsProteomicsProteosomeRefractory DiseaseRegulationResistanceRheumatic DiseasesRheumatismRheumatoid ArthritisRheumatologic DiseasesRheumatologic DisorderRoleSeverity of illnessSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSomatic MutationStrains Cell LinesSymptomsSyndromeT-CellsT-LymphocyteTemporal ArteritisTransgenic MiceTransplantationUbiquitinVacuoleWorkZebra DanioZebra FishZebrafishautoinflammatorybiological signal transductionblood cell formationblood cell progenitorblood disorderblood progenitorblood stem cellblood-forming stem cellbone marrow derived progenitorbone marrow derived stem cellsbone marrow stromal cellbone marrow stromal stem cellcell typeconditional knock-outconditional knockoutcultured cell linedisease severitydrivingeffective therapyeffective treatmentexperimentexperimental researchexperimental studyexperimentsfitnessfloxedfloxed allelegenome mutationheavy metal Pbheavy metal leadhematopoietic progenitorhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellimprovedinhibitorinsightknockinlymph celllymphocyte precursorlymphocyte progenitorlymphocyte stem celllymphoid precursorlymphoid progenitorslymphoid stem cellmodel of animalmortalitymouse modelmulticatalytic endopeptidase complexmurine modelmutantmyeloid precursormyeloid stem and progenitor cellpathwayresistantresponserheumatic arthritissmall moleculesocial rolesomatic variantstem cellssystemic inflammationsystemic inflammatory responsethymus derived lymphocytetransplant
Description preview
Project Summary (<30 lines):
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a newly identified
inflammatory and hematologic disease caused by somatic mutations in UBA1. Individuals with UBA1 mutations
have clinical manifestations similar to well-established rheumatic diseases such as rheumatoid arthritis and giant…
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