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Regulation of IgE production during aeroallergen sensitization

Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 24 May 2024Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY202519S Gamma Globulin7S Gamma GlobulinAffectAirway DiseaseAllergensAllergicAllergic inflammationAntibodiesAsthmaB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBindingBlocking AntibodiesBlood Plasma CellBody TissuesBronchial AsthmaCell BodyCell secretionCellsCellular SecretionClinical ResearchClinical StudyClosure by LigationComplex MixturesDetectionDiseaseDisorderExposure toFilamentous FungiFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGenerationsGoalsGrainHumanIgAIgEIgGIgMImmune responseImmunityImmunochemical ImmunologicImmunoglobulin AImmunoglobulin EImmunoglobulin GImmunoglobulin MImmunologicImmunologic StimulationImmunologicalImmunological StimulationImmunologicallyImmunologicsImmunostimulationIndividualInhalationInhalingLaboratoriesLearningLigationLungLung DiseasesLung Respiratory SystemMethodologyMiceMice MammalsMicroscopyModelingModern ManMoldsMolecular InteractionMurineMusPathogenesisPathogenicityPathway interactionsPersonsPlasma CellsPlasmacytesPollenPopulationPrevalenceProceduresProcessProductionPublic HealthPulmonary Body SystemPulmonary DiseasesPulmonary DisorderPulmonary Organ SystemReceptor ProteinRegulationReporterReproduction sporesRespiratory SystemRespiratory TractsRespiratory tract structureRoleSamplingSpecificitySporesStaining methodStainsTissuesXolairaeroallergensairborn allergenairborne allergenairflow limitationairflow obstructionairway limitationairway obstructionallergic airway diseasedisease of the lungdisorder of the lungdust miteflow cytophotometryhost responseimmune system responseimmunoresponseimprovedinsightlung disordermouse modelmurine modelobstructed airflowobstructed airwayomalizumabparticlepathwayplasma cell differentiationplasmocytepreventpreventingpyroglyphidreceptorrespiratory airway obstructionresponsesocial role

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Project Summary/Abstract
Asthma is a debilitating lung disease marked by reversible airway obstruction that affects over 5% of the US

population and is growing in prevalence. In the majority of cases of asthma, allergic inflammation around the

bronchial airways contributes to disease pathogenesis. A key pathway in the initiation of allergic immune…

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Regulation of IgE production during aeroallergen sensitization β€” UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | UNITED STATES | Dev Procure