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Regulation of GluN2B-NMDA Receptors by Interactions with the Actin Cytoskeleton
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Project Summary
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels composed of transmembrane
GluN1, GluN2 (A-D), and GluN3 (A-B) subunits that mediate Ca2+ influx into the dendritic spine. Importantly, the
unique intracellular tail of the GluN2B subunit is essential for learning and memory. Furthermore, autism
spectrum…
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