grant
Regulation of Gene Transcription
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY20253-D structure3-dimensional structure3D structureArchitectureBacteriophage lambdaBasal Transcription FactorBasal transcription factor genesBindingBiochemicalBiologic ModelsBiological ModelsCell AdhesionCellular AdhesionChemotaxisChromosomal OrganizationChromosomal StructureChromosome OrganizationChromosome StructuresChromosomesColiphage lambdaD-GalactoseDNADNA BindingDNA Binding InteractionDNA Molecular BiologyDNA boundDeoxyribonucleic AcidE coliE. coliElementsEngineering / ArchitectureEnterobacteria phage lambdaEscherichia coliExpression SignatureFRETFluorescenceFluorescence Resonance Energy TransferFörster Resonance Energy TransferGalactopyranoseGalactopyranosideGalactoseGene Action RegulationGene ActivationGene Down-RegulationGene ExpressionGene Expression ProfileGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGenetic TranscriptionGoalsGrowthHU ProteinLabelLaboratoriesMalignant CellMicrobial BiofilmsMicroscopyModel SystemMolecular BiologyMolecular InteractionMotilityOperonPhage lambdaPhysiologicPhysiologicalProphagesRNA ExpressionRepressionResearchSwimmingSystemSystems BiologyTestingTissue GrowthTranscriptionTranscription Factor Proto-OncogeneTranscription RepressionTranscription factor genesWorkbiofilmbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquescancer celldevelopmental geneticsdimergene expression patterngene expression signaturegene repressionglobal gene expressionglobal transcription profilemath methodologymath methodsmathematical approachmathematical methodologymathematical methodsmathematics approachmathematics methodologymathematics methodsnovelontogenysingle moleculesugarthree dimensional structuretranscription factortranscriptional profiletranscriptional signaturetranscriptome
Description preview
(i) We have shown that the chromosome architectural protein HU determines, in an Growth condition dependent way, the expression of motility genes facilitating swimming and chemotaxis and represses the expression of fimbrae genes that facilitate cell adhesion and biofilm formation. (ii) We have determined the mechanisms of interplay between…
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