grant
Regulation of chondrocyte fate and function by ECM Viscoelasticity
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY202521+ years oldAccelerationAdultAdult HumanAffectAge YearsAlginatesAthymic RatsAutoregulationBasal Transcription FactorBasal transcription factor genesBiochemicalBioinformaticsBiologyBiomedical EngineeringBiophysicsBody TissuesBypassCalciumCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium Ion ChannelsCalcium Ion SignalingCalcium SignalingCartilageCartilage injuryCartilaginous TissueCell BodyCell VolumesCell-Extracellular MatrixCellsCellular MechanotransductionChondrocytesClinicalClinical EngineeringCommon Rat StrainsComplexCuesDataDefectDegenerative ArthritisDegenerative polyarthritisDevelopmentDiseaseDisorderECMElasticityEngineeringExhibitsExposure toExtracellular MatrixFDA approvedFemurGelGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGeneticHealthHistologicHistologicallyHomeostasisHumanHydrogelsImmunodeficient MouseImpairmentIn vivo analysisInflammationInflammatoryInternationalIon ChannelIonic ChannelsJointsLaboratoriesLeadMechanical Signal TransductionMechanosensory TransductionMedicalMembrane ChannelsMethodsModelingModern ManMolecularMovementNatureNude RatsOperative ProceduresOperative Surgical ProceduresOsteoarthritisOsteoarthrosisOutcome StudyPathogenesisPathway interactionsPb elementPhenotypePhysiological HomeostasisPreparationProductionPublishingQOLQuality of lifeRNA SeqRNA sequencingRNAseqRatRats MammalsRattusReceptor ProteinRegulationRelaxationResearchRoleSignal PathwaySocietiesStressStretchingSurgicalSurgical InterventionsSurgical ProcedureSystemTestingTherapeuticTissue EngineeringTissuesTranscription Factor Proto-OncogeneTranscription factor genesTransplantationVDCCViscosityVoltage-Dependent Calcium Channelsadulthoodarticular cartilagebio-engineeredbio-engineersbioengineered tissuebioengineeringbiological engineeringbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencesbody movementcartilage cellcartilage developmentcartilage regenerationcartilage repairclinical relevanceclinically relevantcytokinedegenerative joint diseasedevelopmentaldifferential expressiondifferentially expresseddrug developmentefficacy testingengineered tissueheavy metal Pbheavy metal leadhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshypertrophic arthritisin vitro testingin vivoin vivo evaluationin vivo testinginduced human pluripotent stem cellsinsightknock-downknockdownmechanical loadmechanical propertiesmechanosensingmechanotransductionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwaypharmacologicpreparationsreceptorrepairrepairedresponsescaffoldscaffoldingsocial rolesubcutaneoussubdermalsurgerytissue repairtranscription factortranscriptional differencestranscriptome sequencingtranscriptomic sequencingtransplantviscoelasticityvoltage
Description preview
Abstract
Osteoarthritis (OA) is a major disease affecting 1 in 6 adults above 60 years of age in US that significantly impairs
quality-of-life by impacting movement and function. Tissue health and disease is frequently governed by a
complex and non-linear interplay of cell-intrinsic and systemic factors including both biochemical and biophysical…
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