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Regulation of cellular senescence and metabolic health by dietary protein
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 3 Apr 2023Deadline 2 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY202565 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldATP-protein phosphotransferaseAdipose tissueAffectAgeAge related pathologiesAged 65 and OverAgingApoptoticAutomobile DrivingAutoregulationBiology of AgingBody TissuesBranched-Chain Amino AcidsCancersCardiovascular DiseasesCell AgingCell BodyCell Communication and SignalingCell Culture TechniquesCell Cycle ArrestCell SenescenceCell Senescence InductionCell SignalingCellsCellular AgingCellular RegulationCellular SenescenceComplexConsumptionCultured CellsDNA DamageDNA InjuryDasatinibDevelopmentDiabetes MellitusDietDiet CompositionDietary InterventionDietary ProteinsDrugsEatingFGF-21FK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FacultyFatty TissueFellowshipFemaleFibroblastsFood IntakeGene ExpressionGeneticGoalsHealthHealth Care SystemsHigh Protein DietHomeostasisHormone ResponsiveHumanImpairmentIn VitroIncrease lifespanIndividualInflammationInflammatoryIntermediary MetabolismInterventionIntracellular Communication and SignalingInvestigatorsIsoleucineKinase Family GeneL-ValineLength of LifeLeucineLifeLiverLongevityMacronutrientsMacronutrients NutritionMalignant NeoplasmsMalignant TumorMechanistic Target of RapamycinMediatingMedicationMentorshipMetabolicMetabolic ProcessesMetabolic dysfunctionMetabolismMethodsMiceMice MammalsMitochondriaModern ManMolecularMurineMusMuscleMuscle TissueNatureNutrition InterventionsNutritional InterventionsObese MicePathologyPathway interactionsPersonsPharmaceutical PreparationsPhysiological HomeostasisPopulationPredispositionProcessProtein KinaseProteinsPublic HealthQOLQuality of lifeQuercetinRAFT1RapamuneRapamycinRegimenReplicative SenescenceResearch PersonnelResearchersResistanceRisk FactorsRodentRodentiaRodents MammalsRoleSignal TransductionSignal Transduction SystemsSignalingSirolimusStimulusStressSupplementationSusceptibilityTestingTissuesTrainingUnited StatesValineabove age 65adiposeafter age 65age 65 and greaterage 65 and olderage 65 or olderageage associated diseaseage associated disorderage associated impairmentage associated pathologiesage dependent diseaseage dependent disorderage dependent impairmentage dependent pathologiesage induced pathologiesage of 65 years onwardage related human diseaseage-related diseaseage-related disorderage-related impairmentagedaged 65 and greateraged 65+aged miceaged mouseaged ≥65agesaging associatedaging associated pathologiesaging delayaging dependent pathologiesaging induced pathologiesaging pathologiesaging preventionaging relatedaging related pathologiesanti aginganti geronicantiagingattenuate agingattenuation of senescencebiological signal transductionboost longevitybranched amino acidsburden on familiesburden to familiescardiovascular disordercell culturecell culturescell growth regulationcellular aging inductioncellular senescence inductiondecelerate agingdecrease senescencedelay age relateddelay senescencedevelopmentaldiabetesdiet interventiondiet-associated obesitydiet-induced obesitydiet-related obesitydietarydietary compositiondietary manipulationdietsdrivingdrug/agentelderly miceelongating the lifespanenhance healthspanenhance longevityexperimentexperimental researchexperimental studyexperimentsextend healthspanextend life spanextend lifespanextend longevityextending healthy lifespanfamilial burdenfamily burdenfibroblast growth factor 21foster longevityfrailtygeroprotectantgeroprotectivegeroprotectorglobal gene expressionglobal transcription profileglycogen synthase a kinasehallmarks of aginghealthspan extensionhealthy aginghealthy human aginghepatic body systemhepatic organ systemhuman old age (65+)hydroxyalkyl protein kinaseimprove healthspanimprove lifespanimprove longevityimprovedin vivoincrease healthspaninsightintervention enhancing longevityintervention to extend lifespanintervention to improve lifespanintervention to increase longevityintervention to prolong lifespanintervention to promote longevitylife spanlifespanlifespan extending interventionlifespan extending therapieslifespan extensionlifespan improving interventionlifespan increasing interventionlifespan increasing therapieslifespan interventionlifespan prolonging interventionslifespan promoting interventionlongevity boosting interventionlongevity extending interventionlongevity interventionlongevity promoting interventionlongevity therapylongevity treatmentmTORmTOR Inhibitormalemalignancymammalian target of rapamycinmembermid lifemid-lifemiddle agemiddle agedmidlifemitochondrialmortalitymuscularneoplasm/cancerob/ob mouseold miceover 65 yearspathwaypause agingpharmacologicphosphorylase b kinase kinasepillars of agingpostpone age relatedprematureprematuritypreventprevent age relatedprevent agingpreventingpro-agingprogeronicprolong healthspanprolong lifespanprolong longevitypromote agingpromote healthspanpromote lifespanpromote longevityprotein intakeprotein rich dietreduce senescencereducing cellular senescencereplicative agingrepress senescenceresistantresponseretards agingsenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescence inductionsenescence mitigationsenescent associated secretomesenescent associated secretory phenotypesenescent cellsenolyticsskillsslow agingslow down agingslow the rate of agingsocial rolestrategy to enhance longevitystrategy to promote longevitystressorsupport longevitysuppress agingsuppress senescencetenure processtenure tracktranscriptomewhite adipose tissueyellow adipose tissue≥65 years♀♂
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Description preview
PROJECT SUMMARY The number of people over age 65 has more than tripled over the past century, placing
great burdens on families and the healthcare system. Extending healthspan, the portion of the life that is relatively
free from major deficits that impair quality of life, may be the most efficacious way to prevent or delay aging and age-
related…
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