grant

Regulation of cell fate specification to regenerate complex sensory organs

Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Mar 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAgeAmputationAnimalsAppleAutomobile DrivingBody TissuesCNS Nervous SystemCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell Fate ControlCell Fate RegulationCentral Nervous SystemCephalicClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexCranialData SetDevelopmental GeneEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEnvironmentEyeEyeballFresh WaterFreshwaterFutureGene TranscriptionGenetic TranscriptionGenetics-MutagenesisGenomeGoalsHumanInjuryKnowledgeLaboratoriesMalus domesticaMessenger RNAMethodsModern ManMolecularMutagenesisMutagenesis Molecular BiologyNatural regenerationNeuraxisNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesOrganOrganismOutcomePlayProcessRNA ExpressionRegenerationRegenerative MedicineRegenerative capacityRegulatory RegionsResearchRoleSensorySeveritiesSnailsSystemTissuesTranscriptionadult animaladulthoodagescell fate specificationcell typedrivingeye regenerationgene functiongene regulatory networkgenetic regulatory elementinjuriesinsightinterestliving systemmRNAmature animalnew approachesnovel approachesnovel strategiesnovel strategyorgan regenerationoverexpressoverexpressionprogramsregenerateregeneration abilityregeneration capacityregenerativeresponsesocial roletooltranscriptomics
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PROJECT SUMMARY
Some animals have very robust regenerative capacities while others, like humans, have more limited

ones. The severity of the injury, as well as the type of the tissue damaged and the animal age, can all

impact the regeneration outcomes. Sensory organs are of particular interest to regenerative medicine,

as they play a fundamental…

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Regulation of cell fate specification to regenerate complex sensory organs — UNIVERSITY OF CALIFORNIA AT DAVIS | UNITED | Dev Procure