grant
Regulation of Adipose Tissue Plasticity by Pericyte GIPR
NIHUS FederalResearch GrantFY2025AdipocytesAdipose CellAdipose tissueAdult-Onset Diabetes MellitusAdventitial CellAgonistAreaAutomobile DrivingB9 endocrine pancreasBiologyBody TissuesBody Weight decreasedBrainBrain Nervous SystemCRE RecombinaseCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureCommunicationConsensusD-GlucoseDataData SetDevelopmentDextroseDiabetes MellitusDrug TherapyDrugsDysfunctionEatingEncephalonEndocrine Gland SecretionEndocrine PancreasEnsureEnteralEntericEnterobacteria phage P1 Cre recombinaseEventExhibitsFat CellsFatty TissueFood IntakeFunctional disorderGIP receptorGIPRGIPR geneGLP-1GLP-1 receptorGLP-I receptorGene ExpressionGeneticGlp-1GlucoseGlucose-Dependent Insulinotropic PolypeptideGrantHeart VascularHepatic DisorderHind BrainHormonesHumanHumulin RHyperglycemiaIngestionInjectableInsulinIntakeIntermediary MetabolismIntracellular Communication and SignalingInvestigationIslands of LangerhansIslets of LangerhansKetosis-Resistant Diabetes MellitusLineage TracingLipidsLipocytesLiteratureLiverLiver diseasesLoxP-flanked alleleMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMediatingMedicationMetabolicMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManMolecularMolecular FingerprintingMolecular ProfilingMurineMusNIDDMNesidioblastsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNutrientObesityOvernutritionPancreatic IsletsPars endocrina pancreatisPeptidesPericapillary CellPericytesPerivascular CellPharmaceutical PreparationsPharmacological TreatmentPharmacologyPharmacotherapyPhenotypePhysiologicPhysiologicalPhysiologyPhysiopathologyPopulationPropertyPublishingRandomization trialReceptor ActivationReceptor CellReceptor ProteinReceptor SignalingRegular InsulinRegulationReporterResearchRhombencephalonRoleRouget CellsSignal TransductionSignal Transduction SystemsSignalingSiteSkeletal MuscleSlow-Onset Diabetes MellitusSourceStable Diabetes MellitusStrains Cell LinesSubcellular ProcessT2 DMT2DT2DMTestingTherapeutic HormoneTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVoluntary MuscleWeightWeight GainWeight IncreaseWeight LossWeight ReductionWorkadipocyte developmentadipocyte differentiationadipogenesisadiposeadiposityadult animaladult onset diabetesantagonismantagonistbacteriophage P1 recombinase Crebiological signal transductionbody weight gainbody weight increasebody weight losscell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular lineage mappingcellular lineage trackingchronic kidney diseasecirculatory systemclinical applicabilityclinical applicationclinical significanceclinically significantcorpulencecultured cell linedevelopmentaldevelopmental plasticitydiabetesdrivingdrug developmentdrug interventiondrug treatmentdrug/agenteat lessexperimentexperimental researchexperimental studyexperimentsfloxedfloxed allelegastric inhibitory polypeptide receptorgenetic analysisglucagon-like peptide 1glucagon-like peptide-1 receptorglucose-dependent insulinotropic polypeptide receptorhepatic body systemhepatic diseasehepatic organ systemhepatopathyhindbrainhyperglycemicimprovedin vivoingestinsightinsulin sensitivityketosis resistant diabeteslipid biosynthesislipogenesisliver disordermature animalmaturity onset diabetesmolecular profilemolecular signaturemouse geneticsmouse modelmurine modelneuralnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathophysiologypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprecursor cellpromoterpromotorrandomized trialreceptorreceptor expressionreceptor functionreduced eatingreduced food intakeresponsesocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltranscriptomicstype 2 DMtype II DMtype two diabetesuptakeweightswhite adipose tissuewt gainwt-lossyellow adipose tissue
Description preview
Project Abstract
Glucose-dependent insulinotropic polypeptide (GIP) is one of two incretins made in the gut and released in
response to food intake. GIP is responsible for communicating with key metabolic tissues to govern the efficient
uptake and metabolism of ingested nutrients. One key target for GIP is adipose tissue, which expresses the GIP…
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