grant
Regulation and Role of Phosphatidate Phosphatase in Lipid Metabolism
Organization RUTGERS, THE STATE UNIV OF N.J.Location PISCATAWAY, UNITED STATESPosted 1 Jun 2020Deadline 31 May 2030
NIHUS FederalResearch GrantFY20251,2-diacylglycerol3-sn-Phosphatidate phosphohydrolaseATP-protein phosphotransferaseAdult-Onset Diabetes MellitusAutoregulationCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCephalinsCholine GlycerophospholipidsCholine PhosphoglyceridesComplexCongenital dyserythropoietic anemiaCytosolDNA mutationDefectDephosphorylationDiacylglycerolsDiglyceridesDiseaseDisorderEndoplasmic ReticulumEnzyme GeneEnzymesErgastoplasmEthanolamine PhosphoglyceridesEthanolamineglycerophospholipidsFatty LiverGene ExpressionGeneralized GrowthGenesGenetic ChangeGenetic DiversityGenetic VariationGenetic defectGenetic mutationGoalsGrowthHealthHomeostasisHumanInflammationInsulin ResistanceKetosis-Resistant Diabetes MellitusKinase Family GeneLecithinLipidsLipodystrophyLiver SteatosisLocationMaturity-Onset Diabetes MellitusMediatingMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetabolic DiseasesMetabolic DisorderMiceMice MammalsModern ManMurineMusMutationMyoglobinuriaNIDDMNatureNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNuclearO-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)-ethanolamineObesityPNS DiseasesPeripheralPeripheral Nerve DiseasesPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPhosphatasesPhosphatidate PhosphatasePhosphatidate PhosphohydrolasePhosphatidesPhosphatidic Acid PhosphatasePhosphatidic Acid PhosphohydrolasePhosphatidylcholinesPhosphatidylethanolaminePhosphohydrolasesPhospholipidsPhosphomonoesterasesPhosphoprotein PhosphatasePhosphoprotein Phosphatase-2CPhosphoprotein PhosphohydrolasePhosphoric Monoester HydrolasesPhosphorylationPhysiological HomeostasisPlayProcessProtein DephosphorylationProtein KinaseProtein Phosphatase CProtein Phosphatase GeneProtein Phosphatase-1Protein Phosphatase-2AProtein PhosphorylationProtein phosphataseRegulationRhabdomyolysisRoleSlow-Onset Diabetes MellitusStable Diabetes MellitusSubcellular ProcessSurface ProteinsT2 DMT2DT2DMThesaurismosisTissue GrowthTranscriptional ControlTranscriptional RegulationTriacylglycerolTriglyceridesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWorkYeast Model SystemYeastsadipogenesisadiposityadult onset diabeteschronic recurrent multifocal osteomyelitiscorpulencederepressiondiacylglyceroldiglyceridefat metabolismgene synthesisgenome mutationglycogen synthase a kinasehepatic steatosishepatosteatosishydroxyalkyl protein kinaseinsightinsulin resistantinsulin toleranceketosis resistant diabeteslipid biosynthesislipid metabolismlipinlipinelipogenesismaturity onset diabetesmembrane structuremetabolism disorderneonatal periodontogenyoverexpressoverexpressionphosphatidatephosphorylase b kinase kinasesocial roletraffickingtype 2 DMtype II DMtype two diabetesyeast model
Description preview
SUMMARY
Phosphatidate (PA) phosphatase (PAP) is an evolutionarily conserved enzyme that plays a key role in lipid
homeostasis by controlling the cellular levels of its substrate, PA, and its product, diacylglycerol. These lipids are
essential intermediates for the synthesis of triacylglycerol and membrane phospholipids; they also function in…
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