grant
Regulation and Function of WIP1 Phosphatase and its Role in Tumor Cells
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AblationActinic RaysActive SitesAnimalsAntigen PresentationAntioncogene Protein p53AssayBindingBinding SitesBioassayBiochemicalBiochemistryBiologicalBiological AssayBiological ChemistryBiophysicsBlood NeutrophilBlood Polymorphonuclear NeutrophilBrainBrain Nervous SystemCRE RecombinaseCSAID-Binding Protein 1CSAID-Binding Protein 2CSBP2CancersCatalysisCatalytic CoreCatalytic DomainCatalytic RegionCatalytic SiteCatalytic SubunitCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCellsCellular ProliferationCellular Tumor Antigen P53CharacteristicsChemotherapy ProtocolChemotherapy RegimenChemotherapy-Oncologic ProcedureCombination Chemotherapy RegimenCombining SiteComplexCrossbreedingCytokine-Suppressive Antiinflammatory Drug-Binding Protein 1Cytokine-Suppressive Antiinflammatory Drug-Binding protein 2Cytotoxic cellDNA DamageDNA InjuryDataData BasesDatabasesDevelopmentDifferential Gene ExpressionDiseaseDisorderEmbryoEmbryonicEncephalonEnterobacteria phage P1 Cre recombinaseEnzyme GeneEnzymesExtracellular Signal-Regulated Kinase GeneFamilyGene Action RegulationGene Copy NumberGene DosageGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneralized GrowthGenesGenetic HybridizationGenetic TranscriptionGoalsGrowthHealthHigh Throughput AssayHumanImmune Cell ActivationImmune systemIonizing Electromagnetic RadiationIonizing radiationIonsJournalsK lymphocyteKineticsLLC1Lewis lung carcinoma cellLinkLoxP-flanked alleleLung NeoplasmsLung TumorLytotoxicityMAP Kinase GeneMAPKMAPK14MAPK14 Mitogen-Activated Protein KinaseMAPK14 geneMagazineMagnesiumMalignant CellMalignant NeoplasmsMalignant TumorMarrow NeutrophilMethodsMg elementMg(2+)-dependent serine-threonine protein phosphataseMiceMice MammalsMitogen-Activated Protein Kinase 14Mitogen-Activated Protein Kinase GeneModelingModern ManMolecular Dynamics SimulationMolecular InteractionMurineMusMutateMxi2NK CellsNational Institutes of HealthNatural Killer CellsNeurodevelopmental DisorderNeurological Development DisorderNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteNitrogenNormal CellO elementO2 elementOncogenesisOncoprotein p53OrganoidsOutcomeOxygenP53PP2CPPM1DPPM1D genePathway interactionsPatientsPhagocytosisPhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoprotein P53Phosphoprotein pp53Phosphoric Monoester HydrolasesPhysiologicPhysiologicalPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProtein Serine/Threonine PhosphataseProtein Serine/Threonine Phosphatase GeneProtein TP53ProteinsPtc2 phosphatasePulmonary NeoplasmsQuimioterapiaRNA ExpressionRNA SeqRNA sequencingRNAseqRadiation therapyRadiation-Ionizing TotalRadiotherapeuticsRadiotherapyReactive SiteRegulationReportingResearchResistanceResolutionRoleS elementSAPK2ASerine/Threonine Specific Protein Phosphatase GeneSerine/Threonine-Specific Protein Phosphatase GeneStressStress-Activated Protein Kinase 2AStructureSulfurTP53TP53 geneTRP53TestingTissue GrowthTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTumor CellTumor Protein p53Tumor Protein p53 GeneTumor Suppressor ProteinsUV lightUV radiationUV raysUltraviolet RaysUnited States National Institutes of HealthVariantVariationVesicleanalyze gene expressionbacteriophage P1 recombinase Crebiologicbiophysical foundationbiophysical principlesbiophysical sciencescancer cellcancer chemotherapycancer progressionchemical libraryclinical centercytotoxicitydata basedevelopmentalexperimentexperimental researchexperimental studyexperimentsfloxedfloxed allelegain of functiongene expression analysisgene expression assayhigh throughput screeningimmune activationimprovedinhibitorinsightionizing outputloss of functionlung cancer cellmalignancymembermolecular dynamicsneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionneuralneurodevelopmental diseaseneurogenesisneutrophilontogenyoverexpressoverexpressionp38p38 MAP Kinasep38 MAPK Genep38 Mitogen Activated Protein Kinasep38 Protein Kinasep38 SAPKp38-Alphap38Alphap53 Antigenp53 Genesp53 Tumor Suppressorpathwayphosphatase inhibitorpromoterpromotorprotein p53protein phosphatase 2Cradiation treatmentresistantresolutionsserine-threonine phosphatasesmall molecule librariessocial rolesubcutaneoussubdermalsymbionttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtreatment with radiationtumortumor growthtumor progressiontumor suppressortumorigenesisultra violet lightultra violet radiationultra violet raysultraviolet lightultraviolet radiationvirtual screeningvirtual screenings
Description preview
The wild-type p53-induced phosphatase Wip1 (PP2Cdelta or PPM1D) is a member of the serine/threonine protein phosphatase 2C (PP2C) family. Although Wip1 is expressed at low levels in most normal cells, its transcription is induced by p53 after exposure of cells to DNA damage-inducing agents, such as ionizing radiation (IR) or ultraviolet (UV)…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click