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Regulation and function of CCR2 on T cells in Rheumatoid Arthritis
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2026 β οΈ
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAffectAreaAssay for Transposase-Accessible Chromatin using sequencingAtrophic ArthritisAutoimmune DiseasesAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBioinformaticsBiometricsBiometryBiostatisticsBloodBlood Reticuloendothelial SystemBone MarrowBone Marrow Reticuloendothelial SystemCCL2CCL2 geneCCR2 receptorCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCartilageCartilaginous TissueCell BodyCell LocomotionCell MigrationCell MovementCellsCellular MigrationCellular MotilityChemokine Receptor GeneChemokine, CC Motif, Ligand 2Chemotactic CytokinesChimeraChimera organismChronicCollagen ArthritisCollagen-Induced ArthritisDataDedicationsDevelopmentDiseaseDisorderELISAEnvironmentEnzyme-Linked Immunosorbent AssayFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGoalsHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHeterogeneityHomologous Chemotactic CytokinesHumanImmuneImmunesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologyInducer CellsInducer T-LymphocytesInfiltrationInflammatoryInflammatory ArthritisIntegral Membrane ProteinIntercrinesIntrinsic Membrane ProteinInvestigationInvestigatorsJointsKnock-outKnockoutLab FindingsLaboratory FindingLymphocyte BiologyMCAFMCP-1MCP-1 receptorMCP1MacrophageMemoryMentorsMiceMice MammalsModelingModern ManMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMononuclearMurineMusMyeloid CellsMΟPBMCPathogenesisPathologyPatientsPeripheral Blood Mononuclear CellPersonsPopulationPositionPositioning AttributeProductionRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor ProteinRegulationResearchResearch PersonnelResearchersRheumatoid ArthritisRoleSCYA2SIS cytokinesSmall Inducible Cytokine A2SynoviaSynovial FluidSynovitisSystemT cell infiltrationT memory cellT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTherapeuticTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransmembrane ProteinTransmembrane Protein GeneUnited StatesWorkassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingautoimmune conditionautoimmune disorderautoimmunity diseasebonecandidate identificationcell motilitychemoattractant cytokinechemokinechemokine receptorchimerasclustered regularly interspaced short palindromic repeats screencytokinedevelopmentaldrivingenzyme linked immunoassayexperienceflow cytophotometryglobal gene expressionglobal transcription profileinflamed jointinflamed synovial tissueinflamed synoviumjoint inflammationjoint swellingmemory T lymphocytemigrationmonocyte chemoattractant protein 1 receptormouse modelmultiplex assaymurine modelprogramspromoterpromotorreceptorrecruitrheumatic arthritisskillssocial rolesynovial inflammationsystemic autoimmune diseasesystemic autoimmune disorderthymus derived lymphocytetooltranscription factortranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomics
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Description preview
Abstract
Rheumatoid Arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the
synovium and infiltration of mononuclear cells into the joint. Once in the joint the mononuclear cells,
predominantly T cells and macrophages, contribute significantly to disease pathology, yet the mechanism by
which these cells enterβ¦
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