grant
Regulating Cellular Metabolism and Energy Flow to Target Thrombosis
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 Sept 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AblationActive OxygenAddressAdenosineAffectAgingAgonistAntiplatelet AgentsAntiplatelet DrugsApoplexyArteriesAssayAttentionBioassayBiological AssayBleedingBleeding TimeBleeding time procedureBlood NeutrophilBlood PlateletsBlood Polymorphonuclear NeutrophilBlood SampleBlood VesselsBlood leukocyteBlood specimenBrain Vascular AccidentCardiac infarctionCardiovascular DiseasesCarotid Artery ThrombosisCarotid ThrombosisCell BodyCell Communication and SignalingCell SignalingCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCitric Acid CycleClipCoenzyme IIDiseaseDisorderDrugsDysfunctionEconomicsEnergy ExpenditureEnergy MetabolismEnzyme GeneEnzymesEventExhibitsFunctional disorderFutureGenerationsGlycolysisHealthHemorrhageHemostasisHemostatic functionHumanImmunology procedureInflammationInjuryIntermediary MetabolismIntracellular Communication and SignalingKrebs CycleLaser ElectromagneticLaser RadiationLaser injuryLasersLeukocytesLeukocytes Reticuloendothelial SystemLinkMalatesMarrow NeutrophilMarrow leukocyteMarrow plateletMediatingMedicationMesentericMesenteryMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMiceMice MammalsMicrofluidicsMitochondriaModelingModern ManModernizationMolecularMurineMusMutant Strains MiceMyelogenousMyeloidMyocardial InfarctMyocardial InfarctionNAD phosphateNAD(H) phosphateNADH phosphateNADPNADPHNeutrophilic GranulocyteNeutrophilic LeukocyteNicotinamide-Adenine Dinucleotide PhosphateOxidasesOxidative PhosphorylationOxidative Phosphorylation PathwayOxygen RadicalsPathway interactionsPatientsPharmaceutical PreparationsPhysiopathologyPilot ProjectsPlatelet ActivationPlatelet Aggregation InductionPlatelet aggregationPlateletsPlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPredispositionPro-OxidantsProcessProductionPyruvateReactive Oxygen SpeciesResearchRestRiskRoleSafetySamplingSaphenous VeinSignal TransductionSignal Transduction SystemsSignalingStrokeSusceptibilityTCA cycleTailTestingTherapeuticTherapeutic InterventionThrombocytesThrombosisTricarboxylic Acid CycleTriphosphopyridine NucleotideWhite Blood CellsWhite CellWild Type Mouseadult youthaerobic glycolysisage associatedage correlatedage dependentage linkedage relatedage specificagedbiological signal transductionblood lossbrain attackcardiac infarctcardiovascular disordercerebral vascular accidentcerebrovascular accidentco-morbidco-morbiditycomorbiditycoronary attackcoronary infarctcoronary infarctiondrug/agenteconomicextracellularheart attackheart infarctheart infarctionhigh riskhuman subjectimmunologic assayimmunologic assay/testin vivoinhibitorinjuriesinnovateinnovationinnovativeinsightintervention therapyintra-vital microscopyintravital microscopyleukocyte activationmalic enzymemetabolism measurementmetabolomicsmetabonomicsmitochondrialmortalitymouse mutantneutrophilnew approachesnew drug classnovelnovel approachesnovel drug classnovel strategiesnovel strategyolder adultolder adulthoodpathophysiologypathwaypharmacologicpilot studypyruvic-malic carboxylaseresponsesocial rolestrokedstrokessuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthromboinflammationthromboinflammatorythromboticthrombotic diseasethrombotic disordertranslational opportunitiestranslational potentialvascularwhite blood cellwhite blood corpusclewildtype mouseyoung adultyoung adult ageyoung adulthoodµfluidic
Description preview
Project summary
Platelets and leukocytes play a crucial role in thrombotic cardiovascular disease (CVD) pathophysiology. While
conventional antiplatelet therapies effectively reduce mortality and nonfatal events in over 50% of high-risk
patients, they also increase the risk of bleeding, a significant concern in modern CVD treatment. Given that the…
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