grant
Regenerative biomaterial for combating genitourinary syndrome of menopause
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 15 Sept 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AffectAgeAnimal ModelAnimal Models and Related StudiesAnimalsAnteriorApoptosisApoptosis PathwayAtrophicAtrophyBiochemicalBiocompatible MaterialsBiomaterialsBiomechanicsBody TissuesCell DifferentiationCell Differentiation processCell Growth in NumberCell MultiplicationCell ProliferationCell-Extracellular MatrixCellular ProliferationChromosome MappingChronicClinicalCollagenDataDeteriorationDevelopmentECMElastic TissueElasticityEpithelial Cell ProliferationEpitheliumEsthesiaEstrogensExtracellular MatrixFemale HealthGene ExpressionGene LocalizationGene MappingGene Mapping GeneticsGeneralized GrowthGenitourinaryGenitourinary systemGrowthHarvestHigh PrevalenceHydrogelsImmune responseImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunomodulationImpairmentIn SituInflammatory InfiltrateInjectableInjectionsIntermediary MetabolismInterventionIntravaginal AdministrationInvoluntary MuscleItchingLLLTLamina PropriaLaser BiostimulationLeannessLinkage MappingLow-Level Laser TherapyLow-Power Laser IrradiationLow-Power Laser TherapyLubricantsMenopausal SyndromeMenopauseMenopause SyndromeMetabolic ProcessesMetabolismMuscle AtrophyMuscular AtrophyOophorectomyOvariectomyPainPainfulPathologicPathway interactionsPerimenopausalPerimenopausePhenotypePre-Clinical ModelPre-MenopausePre-menopausal PeriodPreclinical ModelsPremenopausalPremenopausal PeriodPremenopauseProgrammed Cell DeathProliferatingPropertyPruritic DisorderPruritisPruritusPublic HealthQOLQuality of lifeResearchSERMsSafetySalineSaline SolutionSelective Estrogen Receptor ModulatorsSensationSex FunctioningSkeletal MuscleSmooth MuscleSprague-Dawley RatsSymptomsTestingTherapeuticTherapeutic EstrogenThickThicknessThinnessTimeTissue GrowthTissuesTopical Drug AdministrationTopical applicationTotal Human and Non-Human Gene MappingTreatment EfficacyUpregulationUrogenitalUrogenital SystemVaginaVaginal AdministrationVaginal Drug AdministrationVaginal InstillationsVaginal Route of Drug AdministrationVascularizationVoluntary MuscleWomanWomen's Healthagesalleviate symptomameliorating symptomapply topicallyapply vaginallybiocompatibilitybiological materialbiomaterial compatibilitybiomechanicalcellular differentiationcohortcostdecrease symptomdeliver topicallydeprivationdesigndesigningdevelopmentalfemale gonadectomyfewer symptomsgenetic mappinggenitourinary tracthealthy aginghealthy human aginghost responseimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimprovedin vivoinnovateinnovationinnovativeintervention efficacyintravaginal applicationitch sensationlaser therapymechanical propertiesmenopause transitionminimally invasivemodel of animalmultidisciplinarymuscle breakdownmuscle degradationmuscle deteriorationmuscle lossmuscle wastingneovascularizationnovelontogenypathwayperi-menopausalperi-menopausepre-menopausalpremenopausal statuspreventpreventingreduce symptomsregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueregeneration based therapyregeneration therapyregenerativeregenerative therapeuticsregenerative therapyregenerative tissuerelieves symptomsrepairrepairedsatisfactionsexual functioningside effectspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssuccesssymptom alleviationsymptom reductionsymptom relieftherapeutic efficacytherapy efficacytissue regenerationtissue regrowthtissue renewaltissue specific regenerationtooltopical administrationtopical deliverytopical drug applicationtopical drug deliverytopical instillationtopical treatmenttransition to menopausetransitional menopausetreat topicallyurogenital tractvaginal applicationvaginal drug deliveryvaginal dryness
Description preview
Project Summary
Genitourinary syndrome of menopause (GSM) is an extremely prevalent condition consequent to the
hypoestrogenic changes in the genitourinary tract that affects up to 85% of perimenopausal and menopausal
women. Major symptoms of GSM include vaginal dryness, itching, discomfort, burning, and pain; thus, GSM
significantly impacts…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click