grant
Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 30 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AbscissionAcetylcysteineAcetylinActive Follow-upAddressAdverse ExperienceAdverse eventAffectAirbronAlanineAminoacetic AcidAntioxidantsArthralgiaAutomobile DrivingBiological MarkersBroncholysinBrunacChronicClinicalDegenerative ArthritisDegenerative polyarthritisEnrollmentExcisionExtirpationExtremitiesF2-IsoprostanesFabrolFluatoxFluimucetinFluimucilFluprowitFree RadicalsGlycineHomeHome environmentHourInterventionIschemia-Reperfusion InjuryJoint PainKnee arthroplastyKnee jointKnee joint replacement operationKnee replacementLimb structureLimbsLinkLong-term painMediatingMercapturic AcidMuco SanigenMucocedylMucolatorMucolyticumMucomystMucosolvinMucretN-AcetylcysteineNAC ZambonNeo-FluimucilNociceptorsNon-TrunkOperative ProceduresOperative Surgical ProceduresOpiatesOpioidOpioid AnalgesicsOsteoarthritisOsteoarthrosisOtomyOutcomeOxidative StressPainPain ResearchPain intensityPainfulParvolexPathologyPatientsPerioperativePersistent painPhenotypePlacebo ControlPlacebosPost-operative PainPostoperativePostoperative PainPostoperative PeriodProceduresRandomizedRandomized, Controlled TrialsRemovalReperfusion DamageReperfusion InjuryReportingRespaireRiskSham TreatmentSubgroupSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSurgical incisionsTestingTimeTixairTotal Knee ReplacementTourniquetsWorkactive followupbio-markersbiologic markerbiomarkerchronic painconstant paindegenerative joint diseasedesigndesigningdrivingenrollexperiencefollow upfollow-upfollowed upfollowupfunctional improvementfunctional outcomeshomeshypertrophic arthritisimprove functionimprovedimproved functional outcomesin vivoincisioninnovateinnovationinnovativeknee replacement arthroplastylasting painnerve injuryneural injurynociceptive neuronsolder adultolder adulthoodon-going painongoing painopiate analgesiaopiate analgesicopiate consumptionopiate drug useopiate intakeopiate pain medicationopiate pain relieveropiate useopioid analgesiaopioid anestheticopioid consumptionopioid drug useopioid intakeopioid pain medicationopioid pain relieveropioid painkilleropioid usepain after surgerypain outcomepain reductionpain-related outcomepain-sensing neuronspain-sensing sensory neuronspain-sensing somatosensory neuronsplacebo controlledpost-surgical painpostsurgical painprecision medicineprecision-based medicinepreventpreventingprospectivepsychosocialrandomisationrandomizationrandomized control trialrandomized placebo control trialrandomized placebo controlled trialrandomly assignedreduce painresectionsham therapystress reductionsuccesssurgerytotal knee arthroplasty
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Abstract
Approximately 1 million total knee arthroplasty (TKA) procedures are carried out in the U.S. annually to
address pathology underlying knee joint pain and functional limitations resulting from osteoarthritis. TKAs are
conducted primarily in older adults, and while effective for pain reduction in many, 15% or more of TKA
patients report…
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