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Reducing Hyperinsulinemia and Insulin Resistance in Type 1 Diabetes Using Adjunctive Therapies
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 May 2024Deadline 1 Sept 2025 ⚠️
NIHUS FederalResearch GrantFY2025AddressAdipose tissueAdult-Onset Diabetes MellitusAffectBody TissuesBrittle Diabetes MellitusCardiovascular DiseasesChronicCirculationCo-TransportersCross-Over StudiesCrossover StudiesD-GlucoseDataDevelopment and ResearchDextroseDiabetes MellitusDiseaseDisorderDoseDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyEuglycemic ClampingEuglycemic-hyperinsulinemic ClampFastingFatty TissueGlucagon ReceptorGlucoseGlucose ClampGoalsHealthHepaticHormonalHumanHumulin RHyperinsulinemiaHyperinsulinemic ClampHyperinsulinismIDDMImpairmentIndirect CalorimetryIndividualInsulinInsulin ResistanceInsulin-Dependent Diabetes MellitusJuvenile-Onset Diabetes MellitusK23 AwardK23 MechanismK23 ProgramKetosis-Prone Diabetes MellitusKetosis-Resistant Diabetes MellitusKidneyKidney Urinary SystemLiverMaturity-Onset Diabetes MellitusMeasurementMeasuresMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)MentorsMentorshipMetabolicMetabolic Clearance RateMissionModern ManMuscleMuscle TissueNIDDKNIDDMNa elementNational Institute of Diabetes and Digestive and Kidney DiseasesNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RParticipantPb clearancePeripheralPersonal SatisfactionPersonsPhysiciansPlacebo ControlPlacebosPopulationPositionPositioning AttributePrincipal InvestigatorPublic HealthQOLQuality of lifeR & DR&DRegular InsulinResearchResearch TechnicsResearch TechniquesResearch TrainingRespiration CalorimetryScientistSham TreatmentSkeletal MuscleSlow-Onset Diabetes MellitusSodiumStable Diabetes MellitusSudden-Onset Diabetes MellitusT1 DMT1 diabetesT1DT1DMT2 DMT2DT2DMTestingTherapeuticTherapeutic InterventionTimeTissuesTracerTrainingTreatment PeriodType 1 Diabetes MellitusType 1 diabetesType 2 Diabetes MellitusType 2 diabetesType I Diabetes MellitusType II Diabetes MellitusType II diabetesVoluntary MuscleWorkabsorptionadiposeadult onset diabetesantagonismantagonistcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular riskcardiovascular risk factorcareer developmentclearance ratediabetesexperiencefastedfastsglycemic controlhepatic body systemhepatic organ systemhyperglucagonemiaimprovedinhibitorinnovateinnovationinnovativeinsightinsulin dependent diabetesinsulin dependent type 1insulin resistantinsulin sensitivityinsulin toleranceintervention therapyjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesketosis resistant diabeteslead clearancematurity onset diabetesmultidisciplinarymuscularnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachplacebo controlledrenalresearch and developmentrisk mitigationsham therapyskill acquisitionskill developmentstable isotopesubcutaneoussubdermalsuccesssymportertreatment daystreatment durationtype 2 DMtype I diabetestype II DMtype one diabetestype two diabeteswell-beingwellbeingwhite adipose tissueyellow adipose tissue
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PROJECT SUMMARY/ABSTRACT
Peripheral insulin administration and impaired insulin clearance lead to hyperinsulinemia and insulin resistance
in individuals with type 1 diabetes (T1D). As independent risk factors for cardiovascular disease (CVD),
hyperinsulinemia and insulin resistance contribute to the high burden of CVD experienced by this…
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