grant

Reciprocal genetics of recently-evolved vertebrate immunity and helminth counter-adaptation

Organization UNIVERSITY OF CONNECTICUT STORRSLocation STORRS-MANSFIELD, UNITED STATESPosted 14 Jul 2017Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AdjuvantAffectAlum AdjuvantAnimalsAttenuatedBiologic ModelsBiological ModelsBlood Coagulation Factor IBlood Coagulation Factor OneBlood Factor OneBody TissuesBody cavitiesBreedingCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell-Extracellular MatrixCestodaCestode InfectionsCestodesChromosome MappingChronicCicatrixClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCoagulation Factor ICoagulation Factor OneCollagenConcurrent StudiesDecline in mobilityDecrease in mobilityDecreased mobilityDiminished mobilityDiseaseDisorderECMEncapsulatedEpistasisEpistatic DeviationEvolutionExhibitsExperimental ModelsExtracellular MatrixFactor IFactor OneFecundabilityFecundityFertilityFibrinogenFibrosisFishesFresh WaterFreshwaterGWA studyGWASGasterosteidaeGene LocalizationGene MappingGene Mapping GeneticsGeneralized GrowthGenesGeneticGenetic DiversityGenetic EpistasisGenetic ScreeningGenetic VariationGenomicsGenotypeGeographyGoalsGrowthHelminthsHeritabilityHistoryHost resistanceHumanHybridsIP injectionImmuneImmune EvasionImmune responseImmune systemImmunesImmunityImmunochemical ImmunologicImmunogeneticsImmunologicImmunologicalImmunologicallyImmunologicsInfectionInflammationInflammatory ResponseInjectionsInteraction DeviationIntraperitoneal InjectionsLesionLinkage MappingLong-term infectionMapsMobility declineMobility impairmentModel SystemModelingModern ManMorbidityNematodaNematodesOutcomeParasitesParasitic WormsPathologicPathologyPathway interactionsPeritonealPeritoneumPhenotypePopulationProteinsProteomicsQTLQuantitative Trait LociRecording of previous eventsRecoveryReduced mobilityReduction in mobilityReproductionResearchResistanceRiskScarsSclerosisSeveritiesSpeedSticklebackSystemTapeworm InfectionTapewormsTestingTherapeuticTherapeutic InterventionTissue GrowthTissuesTotal Human and Non-Human Gene MappingVariantVariationVertebrate AnimalsVertebratesWorkalumaluminum sulfatearms raceattenuateattenuatesattenuationbody cavitychronic infectioncostepistatic interactionepistatic relationshipgene x gene interactiongenetic analysisgenetic epistasesgenetic mappinggenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyhelminth infectionhelminthic infectionhistorieshost responseimmune evasiveimmune system responseimmunoresponseinfected with helminthintervention therapymodel organismmortalityontogenyparasite genomepathwaypersistent infectionpublic health relevanceresistantresponseroundwormsuccesssynergismsystems researchtheoriestooltraittranscriptomicsvertebratawhole genome association analysiswhole genome association study
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PROJECT SUMMARY/ABSTRACT
Vertebrates evolved sophisticated immune systems to eliminate infections by helminth parasites

(tapeworms, nematodes). Nevertheless, helminths often succeed in establishing persistent infections

because they evolved strategies to evade or manipulate their host’s immune system. Because of this host-

parasite co-evolution,…

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Reciprocal genetics of recently-evolved vertebrate immunity and helminth counter-adaptation — UNIVERSITY OF CONNECTICUT | Dev Procure