🗂️
Archived grant — no longer open
This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.
grant
Receptor variant-based changes in the role of PACAP in the nucleus accumbens during the transition to ethanol dependence
Organization DREXEL UNIVERSITYLocation PHILADELPHIA, UNITED STATESPosted 1 Sept 2023Deadline 20 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY2025ACTH-Releasing FactorAbsolute ethanolAffectAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcohol dependenceAlcoholsAnimalsAttentionBehavioralBrainBrain Nervous SystemCRF-41CannulasCell BodyCellsChronicCommon Rat StrainsConsumptionCorticoliberinCorticotropin-Releasing FactorCorticotropin-Releasing Factor-41Corticotropin-Releasing HormoneCorticotropin-Releasing Hormone-41CoupledDREADDsDataDependenceDevelopmentDrug TherapyDynorphinsETOHEncephalonEtOH drinkingEtOH useEthanolEthanol dependenceEthyl AlcoholExhibitsG-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGene ExpressionGeneticGlutamatesGoalsGrain AlcoholGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHeavy DrinkingHistoryIndividualInjectionsIntakeIsoformsL-GlutamateLimbic SystemMeasuresMethylcarbinolMiceMice MammalsMicroinjectionsModelingMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuropeptidesNon-Polyadenylated RNANucleus AccumbensOutputPACAPPACAP-27PACAP27Paraventricular Nucleus of ThalamusParaventricular Thalamic NucleusPathway interactionsPeptidesPharmacological TreatmentPharmacotherapyPopulationProcessProtein IsoformsPublishingRNARNA Gene ProductsRatRats MammalsRattusReceptor GeneReceptor ProteinRecording of previous eventsRibonucleic AcidRoleStressStructure of paraventricular nucleus of thalamusSystemTestingTimeTrainingUpregulationVariantVariationalcohol abuse therapyalcohol abuse treatmentalcohol addictionalcohol dependencyalcohol dependentalcohol exposedalcohol exposurealcohol ingestionalcohol intakealcohol product usealcohol treatmentalcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakeattenuationbehavior responsebehavioral responsebinge alcohol consumptionbinge drinkingcombatcomparativecorticotropin releasing hormonedesigner receptors exclusively activated by designer drugsdevelopmentaldrink heavilydrinkingdrug interventiondrug treatmentepisodic drinkingethanol addictionethanol consumptionethanol dependencyethanol dependentethanol drinkingethanol exposedethanol exposureethanol ingestionethanol intakeethanol product useethanol useethanol use disorderexcessive alcohol consumptionexcessive alcohol ingestionexcessive alcohol intakeexcessive drinkingexcessive ethanol ingestionexperimentexperimental researchexperimental studyexperimentsexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolextreme drinkingglutamatergicheavy alcohol usehistoriesknock-downknockdownmRNA Expressionmotivated behaviorneurochemicalneurochemistryneuronalnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspituitary adenylate cyclase activating peptidepituitary adenylate cyclase activating polypeptidepituitary-adenylate cyclase activating peptide 27receptorsocial rolevapor
Applications closed.
Description preview
PROJECT SUMMARY
Stress-related systems undergo a change during the transition to ethanol dependence, such that activation,
which in a non-dependent state may leave unaffected or suppress intake, instead increases consumption. This
effect reversal often coincides with an upregulation in receptor gene expression for stress-related neuropeptides;…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click