grant
Receptor-Targeted Fluorescence-Guided Surgery in Pancreatic Neuroendocrine Tumors
Organization UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTONLocation HOUSTON, UNITED STATESPosted 1 Jul 2022Deadline 28 Feb 2028
NIHUS FederalResearch GrantFY2026AbscissionAddressBackBindingBlood SerumBody TissuesCancer CenterCancer TreatmentCanine SpeciesCanis familiarisCaringCell BodyCell Communication and SignalingCell SignalingCellsChargeChelating AgentsChelatorsClinicClinicalClinical ResearchClinical StudyClinical TrialsColoring AgentsCommon Rat StrainsComparative StudyComplexonsConsensusContracting OpportunitiesContractsContrast AgentContrast DrugsContrast MediaDataDetectionDevelopmentDocumentationDogsDogs MammalsDorsumDoseDrug CompoundingDrug DesignDrug PreparationDyesEarly-Stage Clinical TrialsEffectivenessExcisionExocrine pancreatic insufficiencyExtirpationFeedbackFluorescenceFluorescence AgentsFluorescent AgentsFluorescent DyesFreeze DryingFreeze DryingsGenerationsGoalsGuidelinesHead and Neck CancerHead and Neck CarcinomaHistopathologyHumanIND FilingIND applicationIND packageIND submissionImageImage-Guided SurgeryImaging technologyImpairmentIncidenceInjectionsIntracellular Communication and SignalingIntraoperative ComplicationsInvestigational DrugsInvestigational New Drug ApplicationInvestigational New DrugsIsland Cell TumorIslet Cell NeoplasmIslet Cell TumorLabelLyophilizationMalignant Head and Neck NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryManufacturerMediatingMedical OncologistMetastasisMetastasis to Lymph NodesMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to Lymph NodesMetastatic TumorMetastatic Tumor to Lymph NodesMiceMice MammalsModelingModern ManMolecular InteractionMolecular TargetMultifocal LesionMurineMusNeoplasm MetastasisNormal TissueNormal tissue morphologyOperating RoomsOperative ProceduresOperative Surgical ProceduresOrganOvary CancerP50 MechanismP50 ProgramPDX modelPanNetsPancreas ExcisionPancreatectomyPancreatic Endocrine NeoplasmPancreatic Endocrine TumorPancreatic InsufficiencyPancreatic Neuroendocrine TumorPatient derived xenograftPatient imagingPatientsPenetrationPeptide SynthesisPerformancePeroperative ComplicationsPharmacologyPharmacology and ToxicologyPhasePhase 1 Clinical TrialsPhase I Clinical TrialsPlayPostoperativePostoperative PeriodPre-Clinical ModelPreclinical ModelsPreparationProceduresProductionPropertyPublic HealthQOLQuality of lifeRadiopaque MediaRatRats MammalsRattusReceptor ProteinRecurrent NeoplasmRecurrent tumorRemovalResearchRoleSRIH ReceptorsSYS-TXSafetySecondary NeoplasmSecondary TumorSerumSerum ProteinsSignal TransductionSignal Transduction SystemsSignalingSmall IntestinesSolidSomatostatin ReceptorSomatotropin Release Inhibiting Hormone ReceptorsSpecialized CenterSpecific qualifier valueSpecifiedStaining methodStainsSurgeonSurgicalSurgical InterventionsSurgical OncologySurgical ProcedureSurgical RemovalSurgical marginsSynthesis ChemistrySynthetic ChemistrySystemic TherapyTactileTestingTissuesToxicologyTranslatingVisualizationWorkXenograft Modelanaloganti-cancer therapybiological signal transductioncancer metastasiscancer therapycancer-directed therapycaninecontrast imagingcyaninedeath riskdesigndesigningdetection sensitivitydetermine efficacydevelopmentaldomestic dogefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyfirst in manfirst-in-humanfluorescence-guided surgeryfluorescent dye/probefluorophoregood laboratory practicehead/neck cancerimage-based methodimagingimaging agentimaging approachimaging based approachimaging in patientsimaging methodimaging modalityimaging on patientsimprovedin vivoinnovateinnovationinnovativeintra-operative complicationintra-operative imagingintraoperative imaginglymph node metastasismalignant head and neck tumormanufacturemanufacturing processminimally invasivemodel developmentmodel developmentsmortality riskmulti-modalitymultimodalityneoplasm recurrencenovelnuclear imagingoncologic surgeryovarian cancerpancreas surgerypancreatic NETpancreatic islet neoplasmpancreatic surgerypatient derived xenograft modelpatient populationphase 1 trialphase I protocolphase I trialpre-clinicalpre-clinical safetypre-clinical toxicitypreclinicalpreclinical safetypreclinical toxicitypreparationsprimary end pointprimary endpointradiolabelradiolabelsradiotracerreceptorreceptor bindingreceptor boundresectionsafety studyscale upsecondary end pointsecondary endpointsmall bowelsocial rolesomatostatin analogstandard of caresurgerysurgery outcomesurgical imagingsurgical outcometargeted agenttargeted imagingtheranosticstooltranslational opportunitiestranslational potentialtumortumor cell metastasistumor specificitytumor xenograftuptakexenograft transplant modelxenotransplant model
Description preview
PROJECT SUMMARY
The goal of this proposal is to clinically translate a fluorescently labeled contrast agent that improves surgical
outcomes in patients with pancreatic neuroendocrine tumors (pNETs). Surgery is the main treatment option for
these patients and can be curative if tumors are completely removed. However, the inability to accurately…
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