grant
Rationally designed targeted immunogens to elicit HIV Envelope V2-apex broadly neutralizing antibodies
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 17 Jul 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAdjuvantAdministrative ManagementAdoptive TransferAffinityAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody ResponseAntigenic DeterminantsAntigensApicalApplications GrantsB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBinding DeterminantsBiomedical EngineeringClinical EvaluationClinical TestingClinical TrialsCollaborationsConsensusCyclic GMPDevelopmentElementsEngineeringEpitopesEvaluation StudiesFoundationsFrequenciesGametesGerm CellsGerm LinesGerm-Line CellsGoalsGrant ProposalsGuanosine Cyclic MonophosphateHIVHIV InfectionsHIV Vaccine Trials NetworkHIV envelopeHIV envelope proteinHIV vaccineHIV-1 vaccineHIV/AIDS VaccinesHIV1 vaccineHTLV-III InfectionsHTLV-III-LAV InfectionsHVTNHealthHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsIND FilingIND applicationIND packageIND submissionImmune MonitoringImmunologic MonitoringImmunological MonitoringImmunologyImmunomonitoringInfectionInterventionInvestigational New Drug ApplicationInvestigatorsKI miceKnock-in MouseLAV-HTLV-IIILeadLymphadenopathy-Associated VirusM mulattaM. mulattaMacaca mulattaMacaca rhesusMessenger RNAMiceMice MammalsModelingModern ManMolecularMurineMusNHP modelsOffice of Administrative ManagementPathogenesisPathway interactionsPb elementPolishesProcessProtein EngineeringRegimenReproductive CellsResearch PersonnelResearchersReverse engineeringRhesusRhesus MacaqueRhesus MonkeySHIVScienceSex CellSiteT cell responseT-CellsT-LymphocyteTestingToxicologyTranslatingVaccine DesignVaccinesViralViral DiseasesVirus DiseasesVirus-HIVWorkbasebasesbio-engineeredbio-engineersbioengineeringbiological engineeringbooster dosebooster shotbooster vaccinecGMPchallenge in rhesus macaquesclinical testdeliver vaccinesdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalevaluate vaccinesgenetic protein engineeringheavy metal Pbheavy metal leadhuman immunodeficiency virus vaccineimmunization strategyimmunogenimmunogenicityin vivoinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesinitial cellinnovateinnovationinnovativeknockin micemRNAmanufacturemodel of animalmouse modelmurine modelnano particlenano-sized particlenanoparticlenanosized particleneutralizing antibodynew vaccinesnext generation vaccinesnon-human primatenonhuman primatenonhuman primate modelsnovelnovel vaccinespathwaypre-clinicalpreclinicalprogramsprotein designrational designresearch clinical testingresponserhesus challengerhesus macaque challengerhesus monkey infectionsexual cellsimian HIVsimian human immunodeficiency virusskillssuccessthymus derived lymphocytetoolvaccination protocolvaccination strategyvaccine boostvaccine deliveryvaccine developmentvaccine evaluationvaccine protocolvaccine screeningvaccine strategyvaccine testingviral infectionvirtualvirus infectionvirus-induced diseasewelfare
Description preview
OVERALL: PROJECT SUMMARY
Our primary goal in this IPCAVD program is to develop a germline-targeting priming immunogen for the HIV
Envelope V2-apex broadly neutralizing antibody (bnAb) site. We aim to test its ability to activate V2-apex bnAb
precursors in preclinical animal models and manufacture it under GMP standards for human clinical testing.…
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