grant
Rational Design of Next-Generation Engineered T Cells for Enhanced Cancer Immunotherapy
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AddressAdvanced CancerAdvanced Malignant NeoplasmB cell malignancyB lymphoid malignancyBindingBiologyCAR T cellsCAR modified T cellsCAR-TCAR-TsCD28CD28 geneCachectin ReceptorsCancer ModelCancer TreatmentCancerModelCancersCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCellular FunctionCellular PhysiologyCellular ProcessChronicComplexDataDevelopmentDimerizationEngineeringEnvironmentFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene ExpressionGoalsHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHumanImmune EvasionImmune SurveillanceImmune mediated therapyImmune responseImmunologic SurveillanceImmunologically Directed TherapyImmunosurveillanceImmunotherapyIntracellular Communication and SignalingKnowledgeLigand BindingLigandsMalignant CellMalignant Hematologic NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasuresMemoryModern ManMolecular InteractionOutcomePathway interactionsPatientsPhenotypeProtein DimerizationProtein EngineeringProteinsRNA SeqRNA sequencingRNAseqReceptor ProteinReceptor SignalingResearchSignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSolid NeoplasmSolid TumorStructureSubcellular ProcessT cell differentiationT cells for CART-CellsT-LymphocyteT44TM DomainTNF Receptor Family ProteinTNF Receptor SuperfamilyTNF ReceptorsTNFRTestingTherapeutic EffectTimeTransmembrane DomainTransmembrane RegionTreatment EfficacyTumor Necrosis Factor ReceptorTumor Necrosis Factor Receptor FamilyTumor Necrosis Factor Receptor Superfamilyanti-cancer immunotherapyanti-cancer therapyanticancer immunotherapyarmbiological signal transductioncancer cellcancer immunotherapycancer therapycancer-directed therapychimeric antigen T cell receptorchimeric antigen receptorchimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cellschimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellsclinical efficacycombatdesigndesigningdevelopmentalengineered T cellsexhaustionexperimentexperimental researchexperimental studyexperimentsflow cytophotometrygenetic protein engineeringgenetically engineered T-cellshost responseimmune evasiveimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoresponseimmunotherapy for cancerimmunotherapy of cancerimpaired capacityimprovedin vivoinnovateinnovationinnovativeintervention efficacymalignancyneoplasm/cancernew approachesnext generationnovelnovel approachesnovel strategiesnovel strategypathwaypreventpreventingprotein designrational designreceptorresponsestructural biologysuccesstherapeutic efficacytherapy efficacythymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingtransgenic T- cellstumor
Description preview
PROJECT SUMMARY
A major challenge for engineered T cells to combat cancer is their limited persistence. The goal of this project is
to enhance the persistence of T cells by harnessing 4-1BB using structure-informed protein design. As a co-
stimulatory molecule, 4-1BB improves T cell long-term immune responses. Incorporating the 4-1BB signaling…
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