grant
Rapid Assessment of Proteoform-Resolved Higher-Order Structures
Organization UNIVERSITY OF NEVADA RENOLocation RENO, UNITED STATESPosted 20 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AccelerationAdoptionAutomobile DrivingBiologicalCancersCardiovascular DiseasesCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessChemicalsDegenerative Neurologic DisordersDerivationDerivation procedureDigestionDiseaseDisorderDistalEnsureGoalsHealthHigher Order Chromatin FoldingHigher Order Chromatin StructureHigher Order StructureHumanKnowledgeMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMethodsModelingModern ManMolecular ConfigurationMolecular ConformationMolecular StereochemistryNatureNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsPeptidesPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProtein ModificationProteinsProteomicsReagentRegulationReportingReproducibilityResearch ProposalsSamplingSeriesSpectrometrySubcellular ProcessSystemTechniquesTherapeutic Interventionbiologiccardiovascular disordercomplex biological systemsconformationconformationalconformational stateconformationallyconformationsdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdiagnostic abilitydiagnostic capabilitydiagnostic powerdiagnostic utilitydiagnostic valuedrivingdrug developmentdrug discoveryimprovedinsightintervention therapyion mobilitymalignancyneoplasm/cancerneurodegenerative illnessnew drug targetnew druggable targetnew pharmacotherapy targetnew technologynew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel technologiesnovel therapeutic targetnovel therapy targetprotein functiontool
Description preview
Project Description
To perform their multitude of functions, proteins often bring—distal in sequence—residues together and fold
into reproducible higher-order structures (HOS). Ensuring the integrity of this orientation or intentionally
modulating it through post-translational modification (PTM) are vital processes that are known to be perturbed…
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