grant
Raman spectroscopic platform for transcutaneous monitoring of bone quality
Organization UNIVERSITY OF ROCHESTERLocation ROCHESTER, UNITED STATESPosted 1 Jul 2016Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AddressAffectAgeAlgorithmsAmericanAnatomic SitesAnatomic structuresAnatomyBMIBMI percentileBMI z-scoreBiochemicalBody TissuesBody mass indexBone DensityBone DiseasesBone Mineral DensityCadaverCell Communication and SignalingCell SignalingClassificationClinicClinical ResearchClinical StudyComplementComplement ProteinsCoxaDEXADXADataData SetDiagnosisDiagnosticDigital X-RayDistalDual-Energy X-Ray AbsorptiometryDual-Energy Xray AbsorptiometryEarly InterventionEarly identificationEconomic BurdenEnrollmentExtremitiesFemaleFoundationsFractureFundingFutureHandHeterogeneityHipHip FracturesHip region structureHumanHuman VolunteersIR/UV/Raman SpectroscopyIlluminationIncidenceIntracellular Communication and SignalingLibrariesLightingLimb structureLimbsLocationMeasurementMeasuresMedical centerMetacarpalMetacarpal boneMetacarpusMethodologyMethodsMiceMice MammalsMineralsModern ManMonitorMonte Carlo MethodMonte Carlo algorithmMonte Carlo calculationMonte Carlo procedureMonte Carlo simulationMurineMusNational Institutes of HealthNon-TrunkOpticsOs MetacarpaleOsteoporosisPatientsPeripheralPhalanxPhotonsPhysicians' OfficesPrevalenceProtocolProtocols documentationQuetelet indexRaceRacesRadius FracturesRaman SpectroscopyRaman Spectrum AnalysisRaman imagingRaman spectrometryReportingReproducibilityRetrospective StudiesRiskRisk AssessmentRisk EstimateSafetySamplingScanningScreening procedureSensitivity and SpecificitySignal TransductionSignal Transduction SystemsSignalingSiteSkinSourceSpectroscopySpectrum AnalysesSpectrum AnalysisSpinal ColumnSpineStandardizationSystematicsThickThicknessTissuesUnited States National Institutes of HealthVertebraeVertebralVertebral columnVisitWomanWristaccess disparitiesaccessibility disparitiesagesarmbackbonebiological signal transductionbiomechanical analysesbiomechanical analysisbiomechanical assessmentbiomechanical characterizationbiomechanical evaluationbiomechanical measurementbiomechanical profilingbiomechanical testbonebone disorderbone fracturebone fragilitybone healthbone qualitybone strengthcadavericcadaversclinical relevanceclinically relevantcommunity cliniccomplementationdata acquisitiondata acquisitionsdetectordigital Xraydisparities in accessdosageenrollfallsfracture riskfragility fractureglobal healthhandsimprovedin vivoindividuals with osteoporosisinequality in accessinequity in accessinequity in accessibilityinstrumentationirradiationmalemenmouse modelmurine modelnovelopticalosteoporosis individualsosteoporosis patientsosteoporosis peopleosteoporosis populationosteoporotic boneosteoporotic individualosteoporotic patientsosteoporotic populationpatients with osteoporosispeople with osteoporosispopulation with osteoporosisprimary care providerproviders from primary careproviders of primary careracialracial backgroundracial originresponseretrospective research studyretrospective surveyscale upscreeningscreening toolsscreeningssexskin colorsocio-economicsocio-economicallysocioeconomicallysocioeconomicssoft tissuespine bone structuretoolvolunteerwrist fracture♀♂
Description preview
Osteoporosis (OP) is a global health concern with enormous socioeconomic burdens. Alarmingly, rates of
osteoporosis screening using standard dual-energy x-ray absorptiometry (DXA) are abysmal, which contributes
to high rates of preventable fragility fractures. Our long-term objective is to develop an accessible screening
method based on Raman…
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