grant
Radiation synthetic combinations in high-risk Ewing sarcoma
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 20 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY2026ATAC sequencingATAC-seqATACseqAcetylationAddressAdolescentAdolescent YouthAdolescent and Young AdultAgonistAnimal ModelAnimal Models and Related StudiesAnti-CD40AntigensAssay for Transposase-Accessible Chromatin using sequencingBioinformaticsBiologyBone CancerBp50CD40CDW40CRG-2CRISPRCRISPR/Cas systemCUT&RUNCXCL10CXCL10 geneCancersCell BodyCell Communication and SignalingCell SignalingCellsChildhood CancersChildren's Oncology GroupChromatinChronicCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseClinicClinicalClinical Cooperative GroupsClinical Trial GroupsClinical TrialsClinical Trials Cooperative GroupClustered Regularly Interspaced Short Palindromic RepeatsCombined Modality TherapyCommunitiesDNA DamageDNA InjuryDNA mutationDataDedicationsELISAEWSR1EWSR1 geneEWSR2EnvironmentEnzyme-Linked Immunosorbent AssayEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEwing Sarcoma Breakpoint Region 1Ewing Sarcoma Breakpoint Region 2Ewing's Family of TumoursEwing's Sarcoma/Peripheral Primitive Neuroectodermal TumorEwing's TumorEwings sarcomaFLI1FLI1 geneFli-1 proto-oncogene, ETS transcription factorFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFriend leukemia virus integration 1Fusion Oncogene ProteinsFutureGenetic ChangeGenetic defectGenetic mutationGoalsHDACHDAC AgentHDAC ProteinsHDAC inhibitorHistone DeacetylaseHistone Deacetylase InhibitorHistone deacetylase inhibitionHumanIFI10IFNINP10IP-10ImmuneImmune Cell ActivationImmune infiltratesImmune responseImmune systemImmunesImmunobiologyImmunocompetentImmunologic StimulationImmunological StimulationImmunologyImmunophysiologyImmunostimulationImpairmentIn VitroIn vivo analysisIndividualInferiorInfiltrationInflammationInstitutionInterferonsIntracellular Communication and SignalingInvestigationKnowledgeLaboratoriesLightLocal TherapyLocalized TherapyLow Dose RadiationMGC9013MOB-1MacrophageMalignant Bone NeoplasmMalignant Childhood NeoplasmMalignant Childhood TumorMalignant NeoplasmsMalignant Osseous NeoplasmMalignant Osseous TumorMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant Soft Tissue NeoplasmMalignant TumorMalignant Tumor of the BoneMalignant childhood cancerMetastasisMetastasizeMetastatic Ewing's SarcomaMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethylationMiceMice MammalsModelingModern ManMultimodal TherapyMultimodal TreatmentMurineMusMutationMφNeoplasm MetastasisOperative ProceduresOperative Surgical ProceduresOsseous CancerOutcomePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPediatric Oncology GroupPhotoradiationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPreclinical dataProductionProtein ModificationProteinsRadiationRadiation BiologyRadiation OncologyRadiation therapyRadiobiologyRadiotherapeuticsRadiotherapyRelapseResearchResearch SpecimenSCYB10SIC-1SamplingSarcomaSecondary NeoplasmSecondary TumorSecondary toSignal TransductionSignal Transduction SystemsSignalingSpecimenStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationSurgicalSurgical InterventionsSurgical ProcedureTNFRSF5TNFRSF5 geneTestingTherapeuticTimeTranslatingTreatment EffectivenessTreatment EfficacyTumor Necrosis Factor Receptor Superfamily Member 5 GeneTumor PromotionUnresectableUpregulationWorkanti-cancer researchanti-tumor immune responseassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiological signal transductioncancer diagnosiscancer in a childcancer in childrencancer infiltrating T cellscancer metastasiscancer microenvironmentcancer researchchild with cancerchildhood malignancycohesincombination therapycombined modality treatmentcombined treatmentcytokinedisease modeldisorder modelenzyme linked immunoassayepigeneticallyexperienceexperimentexperimental researchexperimental studyexperimentsflow cytophotometryfusion oncoproteingIP-10gene signaturesgenetic signaturegenome mutationhigh riskhost responsehumanized micehumanized mouseimmune activationimmune cell infiltrateimmune competentimmune microenvironmentimmune system responseimmunogenimmunoresponseimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimprovedin vivoin vivo Modelin vivo evaluationin vivo testinginhibitor druginhibitor therapeuticinhibitor therapyinterestintervention efficacyirradiation responsejuvenilejuvenile humanmalignancymalignant soft tissue tumormembermodel of animalmouse modelmulti-modal therapymulti-modal treatmentmurine modelneoplasm/cancernovelp50patient oriented outcomespediatric cancerpediatric malignancypre-clinicalpreclinicalpreclinical findingspreclinical informationprotein complexradiation responseradiation treatmentresistance to therapyresistant to therapyresponseresponse to radiationscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillsspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstandard of carestatistical analysissuccesssurgerytherapeutic effectivenesstherapeutic efficacytherapeutic resistancetherapy efficacytherapy resistanttooltranslational goaltranslational missiontreatment resistancetreatment with radiationtumortumor behaviortumor cell metastasistumor growthtumor immune microenvironmenttumor infiltrating T cellstumor microenvironmenttumor-immune system interactions
Description preview
This proposal addresses the interplay of key facets of pediatric cancer research: DNA damage, chromatin
accessibility, and the immune response to tumors. The overarching scientific goal of this R01 proposal is to
better understand and treat Ewing tumors with STAG2 (stromal antigen 2) loss, a group of Ewing tumors
associated with greatly inferior…
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