grant
Radiation-induced senescence in the brain microenvironment: Implications for glioblastoma recurrence and therapy
Organization UNIVERSITY OF TEXAS HLTH SCIENCE CENTERLocation SAN ANTONIO, UNITED STATESPosted 16 Apr 2021Deadline 31 Mar 2027
NIHUS FederalResearch GrantFY2025Adjuvant ChemotherapyAdjuvant Drug TherapyAstrocytesAstrocytusAstrogliaBasal Transcription FactorBasal transcription factor genesBrainBrain CancerBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCell BodyCellsDNA AlterationDNA Damage RepairDNA RepairDNA Sequence AlterationDNA mutationDevelopmentDrugsEncephalonGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenetic AlterationGenetic ChangeGenetic InductionGenetic defectGenetic mutationGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGrowthGrowth AgentsGrowth FactorGrowth SubstancesHumanIonizing Electromagnetic RadiationIonizing radiationLigandsMalignant Tumor of the BrainMalignant neoplasm of brainMedicationModalityModelingModern ManMutationNeuroglial NeoplasmNeuroglial TumorPDX modelPatient derived xenograftPatientsPharmaceutical PreparationsPhenotypeProteins Growth FactorsPublishingRadiationRadiation exposureRadiation therapyRadiation-Ionizing TotalRadioresistanceRadiosensitizationRadiotherapeuticsRadiotherapyRecurrenceRecurrentRecurrent NeoplasmRecurrent tumorRefractoryResearchResearch SpecimenResistanceSenotherapeuticSenotherapySequence AlterationSpecimenTemodalTemodarTestingTherapeuticTherapeutic InterventionTissue GrowthTranscription Factor Proto-OncogeneTranscription factor genesTransgenic MiceTumor CellTumor PromotionUnscheduled DNA Synthesisastrocytic gliabrain cellcancer progenitorcancer progenitor cellscancer stem cellcancer stem like cellchemo-/radio-sensitizationdevelopmentaldrug/agentefficacy testinggene signaturesgenetic signaturegenome mutationgenomic alterationglial-derived tumorglioblastoma multiformeimprovedimproved outcomeintervention therapyionizing outputirradiation induced senescencemalignant progenitormalignant stem cellmethazolastonemouse modelmurine modelneoplasm recurrenceneoplastic cellneuroglia neoplasmneuroglia tumornew approachesnovelnovel approachesnovel strategiesnovel strategyoncogenic progenitoroncogenic stem cellsontogenypatient derived xenograft modelpre-clinicalpreclinicalprogenitor like cancer cellradiation caused senescenceradiation induced cell senescenceradiation induced cellular senescenceradiation induced senescenceradiation resistanceradiation resistantradiation sensitizationradiation treatmentradio resistanceradio-/chemo-sensitizationradio-sensitizationradioresistantradiotherapy sensitizationresistance mechanismresistance to therapyresistantresistant mechanismresistant to radiationresistant to therapysenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescence by radiationsenescentsenescent associated secretomesenescent associated secretory phenotypesenescent cellsenolyticsspongioblastoma multiformestem like cancer celltemozolomidetherapeutic resistancetherapeutically effectivetherapy resistanttranscription factortranscriptional reprogrammingtranslation strategytranslational approachtranslational strategytreatment resistancetreatment with radiationtumortumorigenictumors in the brain
Description preview
Abstract
Glioblastomas (GBM) are aggressive and radioresistant brain cancers for which better therapeutic approaches
are desperately needed. GBM patients are treated with 50-60 Gy of ionizing radiation (IR), and concurrent and
adjuvant chemotherapy with temozolomide (TMZ). Radiation still remains the most effective therapeutic
modality for GBM,…
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