🗂️
Archived grant — no longer open
This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.
grant
Rac1 Inhibition for the treatment of medulloblastoma
Organization GEORGETOWN UNIVERSITYLocation WASHINGTON, UNITED STATESPosted 6 Dec 2023Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY20250-11 years oldAdolescentAdolescent YouthAffectAfter CareAfter-TreatmentAftercareAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesApopainApoptosisApoptosis PathwayApoptosis-Related Cysteine Protease Caspase 3AssayAtaxiaAtaxyAttenuatedBasal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayBrainBrain CancerBrain Nervous SystemBreast Cancer CellCASP-3CASP3CASP3 geneCPP-32CPP32CPP32 proteinCPP32BCPP32betaCancersCell BodyCell Communication and SignalingCell CycleCell Cycle ProgressionCell Division CycleCell Growth in NumberCell LocomotionCell MigrationCell MovementCell MultiplicationCell NucleusCell ProliferationCell SignalingCell-Cell AdhesionCellsCellular MatrixCellular MigrationCellular MotilityCellular ProliferationCerebellumChildChild YouthChildren (0-21)Clinical TrialsClosure by LigationCognitiveColorectal CancerComplexCoordination ImpairmentCysteine Protease CPP32Cysteine Protease CPP32 GeneCytoskeletal SystemCytoskeletonDataDevelopmentDiseaseDisorderDissociationDoseDrugsDyssynergiaEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExpression SignatureFamilyFoundationsGLI Family GeneGLI Family ProteinGLI ProteinGLI geneGLI-Kruppel Family Member 2GLI1GLI1 GeneGLI1 ProteinGLI2GLI2 geneGTP PhosphohydrolasesGTPasesGene Expression ProfileGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGeneticGli2 proteinGlioma Associated Oncogene Homolog 1 ProteinGlioma Associated Oncogene Homolog ProteinGlioma-Associated Oncogene HomologGlioma-associated oncogeneGrowthGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesH and EHedgehog (Hh) signal transduction pathwayHematoxylin and EosinHematoxylin and Eosin Staining MethodImmune PrecipitationImmunofluorescenceImmunofluorescence ImmunologicImmunoprecipitationIn Situ Nick-End LabelingIn VitroIncidenceIntracellular Communication and SignalingLaboratoriesLigationLuciferase ImmunologicLuciferasesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignant NeoplasmsMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainMeasuresMediatorMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMedicineMedulloblastomaMiceMice MammalsModelingMolecular InteractionMonitorMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMurineMusNMR ImagingNMR TomographyNeurologic DeficitNeurosphereNuclearNuclear Magnetic Resonance ImagingNucleusPARP Cleavage ProteasePARP Cleavage Protease GenePathway interactionsPatientsPerfusionPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhasePlayProgrammed Cell DeathProliferatingRNA SeqRNA sequencingRNAseqRecurrenceRecurrentRegulationReporterReportingRoleSCA-1SCA-1 GeneSHHSHH geneSREBP Cleavage Activity 1SREBP Cleavage Activity 1 GeneSafetySignal TransductionSignal Transduction SystemsSignalingSmall G-ProteinsSmall GTPasesSonic HedgehogStaining methodStainsSystemTUNELTestingTissue GrowthToxic effectToxicitiesTranscription Factor Proto-OncogeneTranscription factor genesVisualizationYamaYama proteinZeugmatographyattenuateattenuatesbiological signal transductionbreast tumor cellcaspase-3cell motilitycysteine protease P32developmentaldrug/agentefficacy testingepigenetic regulationepigeneticallygene expression patterngene expression signaturegli2 gene productglioma associated oncogene 1glioma associated oncogene family zinc finger 1glioma associated protein 2guanosinetriphosphatasehedgehog signalinghedgehog signaling pathwayhh signaling pathwayin vivoinhibitorintracellular skeletonjuvenilejuvenile humankidsmalignancymigrationmodel of animalmouse modelmurine modelneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachontogenypathwaypharmaceuticalpharmacologicpost treatmentresistance mechanismresistant mechanismrhosmall molecular inhibitorsmall molecule inhibitorsmoothened signaling pathwaysocial rolestandard of careterminal nick end labelingtherapeutic targettraditional therapytranscription factortranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtreatment grouptumortumor growthyoungster
Applications closed.
Description preview
PROJECT SUMMARY
Despite considerable advances in identifying genetic and epigenetic abnormalities in medulloblastoma, many
patients succumb to the disease. In addition, patients who respond to traditional therapy suffer from cognitive
and intellectual deficits. Therefore, there is a dire need to identify novel therapies for treating…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click