grant
Quantitative Imaging of Water Transport and Relaxation Processes in the Brain and in Other Soft Tissues
Organization EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AddressAgingAnatomic SitesAnatomic structuresAnatomyAnisotropyApoplexyArchitectureAxonBiologicalBiological MarkersBiomedical ResearchBiopsyBody TissuesBrainBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TraumaBrain TumorsBrain Vascular AccidentCancer StagingCell BodyCell Communication and SignalingCell ComponentsCell SignalingCell StructureCell membraneCellsCellular StructuresCellularityCerebral StrokeCerebral cortexCerebrovascular ApoplexyCerebrovascular StrokeCharacteristicsClinicClinicalColorColoring AgentsCommunitiesComplexContrast AgentContrast DrugsContrast MediaCytoplasmic MembraneDWI (diffusion weighted imaging)DWI-MRIDataData ScienceDetectionDevelopmentDiagnosisDiagnostic Neoplasm StagingDiameterDiffusionDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDimensionsDiseaseDisorderDoctor of PhilosophyDyesEncephalonEngineering / ArchitectureFoundationsGaussian DistributionGelGleanGoalsHeterogeneityHistologicHistologicallyHistologyHourHydrogen OxideImageIndividualIntracellular Communication and SignalingJointsLengthMR ImagingMR TomographyMRIMRI ScansMRIsMTBIMagnetic Resonance ElastographyMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMapsMathMath ModelsMathematicsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodologyMethodsMicroscopicModelingMonitorMulti-center studiesMulti-center trialMulticenter StudiesMulticenter TrialsNMR ImagingNMR TomographyNeoplasm StagingNeurosciences ResearchNormal DistributionNormal Statistical DistributionNuclear Magnetic Resonance ImagingOutcomePathologicPathologyPathway interactionsPh.D.PhDPhysiologic pulsePlasma MembranePopulationPorosityProcessPropertyPulseRadialRadiopaque MediaRadiusRelaxationResearch SpecimenResolutionSchemeShapesSignal TransductionSignal Transduction SystemsSignalingSpecimenSpectroscopySpectrum AnalysesSpectrum AnalysisStaining methodStainsStatistical DistributionsStrokeStructureTestingTimeTissuesTranslatingTranslationsTraumaTraumatic Brain InjuryTumor StagingUncertaintyVisualizationWaterWorkZeugmatographybench bed sidebench bedsidebench to bed sidebench to bedsidebench to clinicbench to clinical practicebio-markersbiologicbiologic markerbiological signal transductionbiomarkerbrain attackbrain tissuecancer diagnosiscancer imagingcell watercerebral vascular accidentcerebrovascular accidentclinical diagnosticsclinical relevanceclinically relevantdMRIdevelopmentaldiffuseddiffusesdiffusingdiffusion anisotropydiffusion tensor imagingdiffusionsdoubtexperimentexperimental researchexperimental studyexperimentsextracellulargray matterhigh dimensionalityimage-based methodimagingimaging biomarkerimaging markerimaging methodimaging modalityimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedin vivoinnovateinnovationinnovativeinterestinventionmacromoleculemathematic modelmathematical modelmathematical modelingmedical diagnosticmigrationmild TBImild brain traumamild traumatic brain injurymillimeterneuralnew approachesnovelnovel approachesnovel strategiesnovel strategyoncologic imagingoncology imagingpathwaypatient populationphysical modelplasmalemmapre-clinicalpreclinicalquantitative imagingradiologistreconstructionresolutionssoft tissuestatisticsstrokedstrokessub micronsubmicronsubstantia albasubstantia griseatooltractographytranslationtraumatic brain damagetumortumor imagingtumors in the brainwater diffusionwhite matter
Description preview
We continue to invent and develop novel quantitative Magnetic Resonance Imaging (MRI) methods and translate these from "bench to bedside". Specifically, we explore new ways to assess tissue structure and architecture in vivo and non-invasively, primarily by "following the water", which is abundant in tissue, but which resides in various…
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