grant
Quantifying Physiologic and Pathologic Viscoelastic Phases of Biomolecular Condensates by Correlative Force and Fluorescence Microscopy
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 15 Aug 2020Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AddressAgingAtomic Force MicroscopyBasal Transcription FactorBasal transcription factor genesBiological FunctionBiological ProcessBiologyBiophysical ProcessCancersCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChaperoneChromatinComplexCoupledCytoplasmic GranulesDNA mutationDegenerative Neurologic DisordersDiseaseDisorderEngineeringFluorescenceFluorescence Light MicroscopyFluorescence MicroscopyForce MicroscopyGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsImageKnowledgeLengthLinkLiquid substanceMalignant NeoplasmsMalignant TumorMapsMeasurementMediatingMembraneModelingMolecularMolecular ChaperonesMutationNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNon-Polyadenylated RNAOrganismPathologicPathway interactionsPhasePhase TransitionPhysical condensationPhysicsPhysiologicPhysiologicalPlayPrion DiseasesPrion Protein DiseasesPrion-Induced DisorderProcessPropertyProteinsPublic HealthRNARNA ExpressionRNA Gene ProductsRNA-Binding ProteinsRegulationResearchRheologyRibonucleic AcidRoleScanning Force MicroscopySolidStructureSubcellular ProcessTechnologyTestingTimeTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransmissible DementiasTransmissible Spongiform Encephalopathiesbiophysical mechanismcomputational frameworkcomputer frameworkcondensationdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdriving forcefluidgenome mutationgranuleimaginginsightlaser tweezerliquidliving systemmalignancymembrane structurenanoneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronal degenerationoptic tweezeroptical trapsoptical tweezerspathwayprion disorderprion-likeprotein protein interactionsocial rolespongiform degenerationspongiform encephalopathytranscription factorviscoelasticity
Description preview
SUMMARY
Dynamic, membrane-less compartmentalization of subcellular processes via biomolecular condensation is
ubiquitous in living systems. Mounting evidence suggests biomolecular condensation is driven by complex, multi-
component phase transitions that combine liquid-liquid and liquid-solid transitions. During the past five years,
the PI has…
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