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Quantifying bNAb neutralization of the HIV latent reservoir

Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAnti-viral AgentsAntibody TherapyAssayBioassayBioinformaticsBiological AssayCD4 CellsCD4 Lymphocyte CountCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ Cell CountsCD4+ CountsCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell LineCell modelCellLineCellsCellular modelClinicalCloningCo-cultureCocultivationCocultureCoculture TechniquesDNADeoxyribonucleic AcidDetectionDevelopmentFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryHIVHIV-1HIV-IHIV1High Throughput AssayHistoryHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1ImmuneImmune responseImmunesImmunomodulationIn VitroIndividualInfectionInternationalLAV-HTLV-IIILaboratoriesLengthLinkLymphadenopathy-Associated VirusMapsMeasuresMediatingNeutralization TestsNon-Polyadenylated RNAPatientsPhasePhenotypePropertyProtocolProtocols documentationRNARNA Gene ProductsRNA SplicingRecording of previous eventsReporterResistanceResolutionRibonucleic AcidSEQ-ANSamplingSensitivity and SpecificitySequence AnalysesSequence AnalysisSiteSortingSplicingStrains Cell LinesT-Cell ActivationT4 CellsT4 Lymphocyte CountT4 LymphocytesTestingTherapeutic StudiesTherapy ResearchTimeTitrationsTranscriptTranscription ActivationTranscriptional ActivationViralViral BurdenViral LatencyViral LoadViral Load resultViral reservoirVirusVirus LatencyVirus reservoirVirus-HIVactivate T cellsanalysis pipelineanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsantibody based therapiesantibody neutralization testantibody treatmentantibody-based therapeuticsantibody-based treatmentbarrier to testingcohortcombinatorialcostcultured cell linedevelopmentalenv Genesflow cytophotometrygenetic analysisgenetic resistancehigh throughput screeninghistorieshost responsehurdle to testingimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponsein vivolatent HIV reservoirlatent HIV-1 reservoirlatent HIV1 reservoirneutralizing antibodynovelobstacle to testingresistance mutationresistantresistant mutationresolutionssextesting barriertesting hurdletesting obstacle

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Description preview

Project Summary
Broadly neutralizing antibodies (bNAb) against HIV Env represent a novel class of antivirals that have the
potential to neutralize viral entry, while simultaneously activating non-neutralizing immune effector functions.
However, a major obstacle for their clinical use is identifying the virologically suppressed HIV+ patients that…

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Quantifying bNAb neutralization of the HIV latent reservoir — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | UNITED STATES | | Dev Procure