grant
PROX1-dependent epigenetic regulation of phenotypic plasticity during colorectal cancer metastasis
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 15 Jul 2025Deadline 14 Jul 2029
NIHUS FederalResearch GrantFY2025AOF2AcetylationAddressAdvanced CancerAdvanced Malignant NeoplasmAssayBindingBioassayBiological AssayBody TissuesCUT&RUNCancer CauseCancer EtiologyCancersCause of DeathCell BodyCellsCessation of lifeChIP SequencingChIP-seqChIPseqChromatinCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseClinicalCo-ImmunoprecipitationsColonColorectal CancerComplementary DNAComplexDNA mutationDataDeacetylaseDeacetylationDeathDerivationDerivation procedureDevelopmentDisseminated Malignant NeoplasmDistantDoxycyclineDysfunctionEngineeringEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvolutionExhibitsFoundationsFunctional disorderFutureGI Stem cellGene Down-RegulationGene ExpressionGene TranscriptionGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeGoalsHD1HDAC1HDAC1 geneHDAC2HDAC2 geneHeterograftHeterologous TransplantationHistone Deacetylase 1In VitroIntestinalIntestinesKDM1AKDM1A geneKnowledgeLSD1LaboratoriesLicensingLysine-Specific Demethylase 1Lysine-Specific Demethylase 1AMSKCCMalignant NeoplasmsMalignant TumorMediatorMemorial Sloan-Kettering Cancer CenterMetastasisMetastasizeMetastatic CancerMetastatic LesionMetastatic Malignant NeoplasmMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsMolecularMolecular InteractionMurineMusMutationNeoplasm MetastasisNeuroendocrine CellNuRDNuRD complexNucleosomesOperative ProceduresOperative Surgical ProceduresOrganOrganoidsOutcomePatientsPatternPhenotypePhysiciansPhysiopathologyPrimary NeoplasmPrimary TumorProcessProteinsRNA ExpressionRPD3-Like 1RPD3L1Reduced Potassium Dependency 3, Yeast, Homolog-Like 1RepressionResectedResistanceScientistSecondary NeoplasmSecondary TumorSiteSolidSolid NeoplasmSolid TumorSquamous CellStem Cell likeStressSurgicalSurgical InterventionsSurgical ProcedureTestingTherapeuticTissuesTrainingTranscriptionTranscription RepressionTranscription RepressorTranscriptional RepressorVibramycinWorkXenograftXenograft procedureXenotransplantationYAF1alpha-6-DeoxyoxytetracyclinebowelcDNAcancer metastasiscancer progressioncareerchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchromatin remodelingclinical significanceclinically significantco-repressorcofactorcohortcolorectal cancer metastasiscorepressordemethylationderepressiondevelopmentaldriver lesiondriver mutationeffective therapyeffective treatmentepigenetic regulationepigeneticallyfetalfetal progenitorfetal stem cellfunctional lossgastrointestinal stem cellgene co-repressorgene corepressorgene repressiongenetic co-repressorgenetic corepressorgenetic repressorgenome mutationgenome sequencinggut progenitorgut stem cellhistone modificationin vivoinhibitorintestinal progenitorintestinal stem cellsintrahepaticknock-downknockdownmalignancymetastatic colo-rectalmetastatic colo-rectal cancermetastatic colo-rectal carcinomametastatic colon cancermetastatic colorectalmetastatic colorectal cancermetastatic colorectal carcinomaneoplasm progressionneoplasm/cancerneoplastic progressionnon-geneticnongeneticnoveloverexpressoverexpressionpathophysiologypharmacologicpreventpreventingprogenitor capacityprogenitor cell functionprogenitor cell likeprogenitor functionprogenitor-likeprogramspromoterpromotorrecruitresistantscRNA sequencingscRNA-seqshRNAshort hairpin RNAsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall hairpin RNAstem and progenitor cell functionstem and progenitor functionstem cell characteristicsstem cell functionstem-likestemnesssurgerytransdifferentiationtreatment strategytumor cell metastasistumor progressionxeno-transplantxeno-transplantation
Description preview
PROJECT SUMMARY
Metastasis is the leading cause of solid tumor-associated death, yet our understanding of how metastasis
initiating cells acquire the capacity to and colonize distant organs has remained limited, hampering
development of effective treatment strategies. Large genome sequencing efforts have failed to identify
metastasis-specific…
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