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Proton-secreting epithelial cells as key modulators of epididymal mucosal immunity.
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Apr 2021Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DABCD-3AblationAddressAnimalsAntigensAutoimmuneAutoimmune ResponsesAutoimmune StatusAutoimmunityBacterial AntigensBioinformaticsBiologyBlood monocyteBone-Derived Transforming Growth FactorC CellC3XkineCRG-2CX3CL1CX3CL1 geneCXC3CXC3CCXCL10CXCL10 geneCell BodyCell CommunicationCell InteractionCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell-to-Cell InteractionCellsCellular injuryChemotactic CytokinesClear CellCommunicationConfocal MicroscopyCorynebacterium Diphtheriae ToxinDataDevelopmentDiphtheria ToxinDiseaseDisorderDuctDuct (organ) structureEatingEnvironmentEpididymisEpididymitisEpithelial CellsEpitheliumEquilibriumFOXP3FOXP3 geneFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFood IntakeForkhead Box P3GenesGoalsH+ elementHealthHomologous Chemotactic CytokinesHydrogen IonsIDOaseIFI10INP10IP-10ImmuneImmune Cell ActivationImmune ToleranceImmune responseImmune systemImmunesImmunologic ToleranceImmunologyImmunomodulationIndoleamine 2,3-DioxygenaseInfectionInflammationInflammatory ResponseInjectionsInjuryIntercrinesJM2KnowledgeLaboratory StudyLigandsMOB-1MacrophageMaintenanceMale ContraceptionMale Contraceptive AgentsMale ContraceptivesMale InfertilityMale reproductive healthMarrow monocyteMaturation of SpermatozoaMediatorMiceMice MammalsMilk Growth FactorMissionMononuclearMotilityMucosaMucosal ImmunityMucosal TissueMucous MembraneMurineMusMφNational Institutes of HealthNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic InfiltrateParafollicular CellPartner in relationshipPathogenicityPathway interactionsPhagocytesPhagocytic CellPlatelet Transforming Growth FactorPlayPositionPositioning AttributeProtonsPublic HealthRNA SeqRNA sequencingRNAseqReceptor ProteinRegulatory T-LymphocyteReproductive BiologyReproductive PhysiologyResearchRoleSCURFINSCYB10SCYD1SIS cytokinesSpecialized Epithelial CellSpermSperm MaturationSpermatic Cord TorsionSpermatozoaSterilityStructure of thyroid parafollicular cellSurvey InstrumentSurveysSystemTGF BTGF-betaTGF-βTGFbetaTGFβTechniquesTesticlesTesticular TorsionTestisTorsionTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransgenic MiceTregTryptophan 2,3 DioxygenaseTubeTubularTubular formationUnited States National Institutes of HealthWorkamebocytebalancebalance functioncell damagecell injurycell sortingcell typecellular damagechemoattractant cytokinechemokinedamage to cellsdevelopmentalflow cytophotometryfocus on malefocused on mengIP-10host responsehuman maleimmune activationimmune modulationimmune regulationimmune system responseimmune system toleranceimmune unresponsivenessimmunogenimmunologic reactivity controlimmunological paralysisimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseinfertile malesinfertile meninfertility in meninjuriesinjury to cellsinnovateinnovationinnovativeinsightinterdisciplinary approachmalemale antifertility drugmale factor infertilitymale focusedmale reproductive functionsmale reproductive tract healthmale specificmale targetedmatemen facing infertilitymen with infertilitymens reproductive functionsmens reproductive healthmicroorganismmonocytemouse modelmultidisciplinary approachmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenpathwaypreventpreventingreceptorrecruitregulatory T-cellsreproductive health in menresponsesocial rolesperm cellsterilestressortargeted to menthree dimensionaltranscriptome sequencingtranscriptomic sequencingtranscriptomicstryptamine 2,3 dioxygenasezoosperm♂
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Description preview
PROJECT SUMMARY/ABSTRACT
One of the most intriguing and understudied aspects of male reproductive physiology is the ability of the epididymis to
prevent the development of immune responses against autoantigenic spermatozoa, while initiating very efficient immune
responses against pathogens. The long-term goal of this application is to develop new…
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