grant
Proteomic Pipelines for the Quantification of Abundance and Turnover of Post-Translationally Modified Proteins in Aging Studies
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY20252-dimensional20S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAPF-1ATP-Dependent Proteolysis Factor 1AcetylationAdult-Onset Diabetes MellitusAgingAutophagocytosisBiologicalBloodBlood Reticuloendothelial SystemBlood SampleBlood specimenBody TissuesCancersCell-Extracellular MatrixClinical ResearchClinical StudyCommunitiesComplexComputational toolkitComputer softwareDeuterium OxideDevelopmentDiseaseDisorderECMEquilibriumExtracellular MatrixFatsFatty acid glycerol estersGoalsHMG-20HealthHeavy WaterHigh Mobility Protein 20HumanHydrogen OxideIsotopesKetosis-Resistant Diabetes MellitusLabelLengthMacropainMacroxyproteinaseMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMaturity-Onset Diabetes MellitusMeasurementMeasuresMetabolicMetabolic Protein DegradationMethodsMiceMice MammalsModelingModern ManModificationMulticatalytic ProteinaseMurineMusMuscleMuscle AtrophyMuscle TissueMuscular AtrophyNIDDMNerve DegenerationNeuron DegenerationNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusPathologyPeptidesPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProsomeProteasomeProteasome Endopeptidase ComplexProtein BiosynthesisProtein ModificationProtein TurnoverProteinsProteomeProteomicsProteosomePublishingRegulatory Protein DegradationResearchRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleScientistSkeletal MuscleSkinSlow-Onset Diabetes MellitusSoftwareStable Diabetes MellitusSystemT2 DMT2DT2DMTimeTissuesTranslationsType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUbiquitinVoluntary MuscleWaterWater-d2Workabnormal protein homeostasisabnormal proteostasisadult onset diabetesage associated diseaseage associated disorderage associated impairmentage dependent diseaseage dependent disorderage dependent impairmentage related human diseaseage-related diseaseage-related disorderage-related impairmentaging associatedaging relatedautophagybalancebalance functionbiologiccomputational pipelinescomputational platformcomputational toolboxcomputational toolscomputational toolsetcomputerized toolscomputing platformdefective proteostasisdevelopmentalhallmarks of agingin vivoketosis resistant diabeteslife spanlifespanmalignancymaturity onset diabetesmulticatalytic endopeptidase complexmuscle breakdownmuscle degradationmuscle deteriorationmuscle lossmuscle wastingmuscularneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnovelopen sourcepillars of agingprotein degradationprotein homeostasisprotein homeostasis declineprotein homeostasis deficiencyprotein homeostasis dysfunctionprotein homeostasis failureprotein homeostasis lossprotein synthesisproteostasisproteostasis declineproteostasis defectproteostasis deficiencyproteostasis dysfunctionproteostasis dysregulationproteostasis failureproteostasis impairmentproteostasis losssarcopeniasarcopenicsenescent cellsocial roletherapeutic targettooltranslationtwo-dimensionaltype 2 DMtype II DMtype two diabetesuser-friendly
Description preview
Building on our published studies that produced a novel computational workflow to accurately assess protein turnover rates in vivo in mice, we are now developing unique computational workflows to do the same in human studies. Equivalent human studies have unique technical challenges that are associated with metabolic labeling with heavy water. In…
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