grant
Proteomic analysis of hydroxychloroquine prevention trials in T1D, RA and SLE
Organization BENAROYA RESEARCH INST AT VIRGINIA MASONLocation SEATTLE, UNITED STATESPosted 18 Aug 2023Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2024Administrative SupplementAtrophic ArthritisAutoantibodiesAutoimmune DiseasesAutoimmune StatusAutoimmunityBiological MarkersBlood SerumBrittle Diabetes MellitusClinicalClinical TrialsData AnalysesData AnalysisData SetDiseaseDisorderEnsureHydroxychlorochinHydroxychloroquineIDDMImmuneImmunesIndividualInsulin-Dependent Diabetes MellitusInvestigatorsJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusLupus Erythematosus DisseminatusMeasuresOxychlorochinOxychloroquinePatientsPlacebosPreventionPrevention trialProteomeProteomicsPublic HealthResearchResearch PersonnelResearchersRheumatoid ArthritisRiskRunningSLESamplingSerumSerum ProteinsSham TreatmentSudden-Onset Diabetes MellitusSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusT-CellsT-LymphocyteT1 DMT1 diabetesT1DT1DMTestingType 1 Diabetes MellitusType 1 diabetesType I Diabetes Mellitusautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive antibodybio-markersbiologic markerbiomarkerclinical diagnosisdata integrationdata interpretationdisseminated lupus erythematosushigh riskinsulin dependent diabetesinsulin dependent type 1intervention armjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesparent grantplacebo grouppreventpreventingprotein expressionrheumatic arthritisself reactive antibodysham groupsham therapyspecific biomarkerssystemic lupus erythematosisthymus derived lymphocytetreatment armtype I diabetestype one diabetes
Description preview
SUMMARY
This is a request for an Administrative Supplement for the Immune Drivers of Autoimmune Disease (IDAD)
project U01 AI176320 “T cells promoting transitions toward autoimmunity”. The proposed studies for the
Administrative Supplement are within the scope of the active parent grant, focused on understanding the immune
mechanisms underlying…
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