grant
PROTECTIVE CD8 T CELL RESPONSES to TUBERCULOSIS
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 8 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY202521+ years oldAIDS VirusAb-mediated immunityAb-mediated protectionAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdenoviridaeAdenovirusesAdultAdult HumanAnimal ModelAnimal Models and Related StudiesAntibody immunityAntibody protectionAntibody-mediated protectionAntigen PresentationAntigen TargetingAntigensAreaBCG immunizationBCG vaccinationBCG-vaccinatedBacille Calmette-Guerin vaccinatedBacille Calmette-Guerin vaccinationBacillus Calmette-Guerin vaccinationBacillus Calmette-Guérin vaccinationBacteriaBlocking AntibodiesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCell BodyCell CommunicationCell InteractionCell-to-Cell InteractionCellsCessation of lifeChadChimpChimpanzeeClonal ExpansionDeathDiabetes MellitusDiseaseDisorderDrug resistance in MtbDrug resistance in Mycobacterium TuberculosisDrug resistant M TuberculosisDrug resistant MtbDrug resistant Mycobacteria TuberculosisEpidemicFrequenciesGeneralized GrowthGoalsGrowthHIVHost resistanceHumanHuman Immunodeficiency VirusesImmune responseImmune systemImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIn VitroInfectionKO miceKnock-out MiceKnockout MiceKnowledgeLAV-HTLV-IIILYT3LeadLicensingLungLung DiseasesLung ParenchymaLung Respiratory SystemLung TissueLymphadenopathy-Associated VirusM . tuberculosis resistanceM tbM tuberculosisM tuberculosis antigenM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis antigenM. tuberculosis infectionM.tb antigenM.tb infectionM.tuberculosis infectionMTB infectionMTB vaccineMacrophageMediatingMemoryMiceMice MammalsModelingModern ManMolecularMorbidityMorbidity - disease rateMtb antigenMtb drug resistanceMtb resistanceMucosaMucosal TissueMucous MembraneMurineMusMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis antigensMycobacterium tuberculosis infectionMycobacterium tuberculosis resistanceMφNull MousePathway interactionsPb elementPersonsPhagosomesPrimary InfectionProductivityPulmonary DiseasesPulmonary DisorderRecrudescencesRegimenReporterResearchResearch ProposalsResistanceRoleRouteStructure of parenchyma of lungT cell responseT memory cellT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTB immunityTB infectionTB therapyTB treatmentTB vaccineTeff cellTestingTissue GrowthTuberculosisTuberculosis VaccinesVaccinatedVaccinationVaccination acquired immunityVaccination induced immunityVaccine for TBVaccine for TuberculosisVaccinesVirus-HIVadulthoodanti-TB vaccineantibody-mediated immunityantigen-specific T cellsbooster dosebooster shotbooster vaccinedevelop a vaccinedevelop vaccinesdevelopment of a vaccinediabetesdisease of the lungdisorder of the lungdisseminated TBdisseminated tuberculosisdrug resistance M Tuberculosisdrug resistance Mycobacteria Tuberculosisdrug resistant M.tbeffector T cellexhaustexhaustionheavy metal Pbheavy metal leadhost responseimmune system responseimmunity against M. tuberculosisimmunity against Mtbimmunity against Mycobacterium tuberculosisimmunity against TBimmunity against tuberculosisimmunity in tuberculosisimmunity to TBimmunity to tuberculosisimmunogenimmunoresponseimprovedin vitro testingin vivoinfection due to Mycobacterium tuberculosisinnovateinnovationinnovativeinsightlung disordermemory T lymphocytemodel of animalmortalitymtbnext generationnon-human primatenonhuman primatenovelontogenypathwaypreventpreventingprogramsresident memory T cellresistance in M . tuberculosisresistance in Mycobacterium tuberculosisresistantresistant M . tuberculosisresistant Mtbresistant Mycobacterium tuberculosisresponsesocial rolesubcutaneoussubdermalthymus derived lymphocytetissue resident memory T celltraittreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistuberculosis immunitytuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathyvaccine acquired immunityvaccine against M. tuberculosisvaccine against Mtbvaccine against Mycobacterium tuberculosisvaccine against TBvaccine against tuberculosisvaccine associated immunityvaccine boostvaccine candidates against tuberculosisvaccine developmentvaccine effectivenessvaccine strategyvaccine-induced immunityvaccine-induced protection
Description preview
Project Summary. Mycobacterium tuberculosis (Mtb) is a leading cause of human deaths around the world.
Despite eliciting a vigorous immune response, Mtb evolved to adapt to its host and evade clearance. While this
idea was originally based on its ability to survive in the phagosome and avoid antibody immunity, we now know
that Mtb also avoids T…
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