grant
Protective antibody in streptococcal infection models
Organization NEW YORK MEDICAL COLLEGELocation VALHALLA, UNITED STATESPosted 2 Dec 2022Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldAb-mediated immunityAb-mediated protectionAbbreviationsAccountingActive immunityAdultAdult HumanAgeAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntibody immunityAntibody protectionAntibody-mediated protectionAntigen TargetingAntigensAutoimmune DiseasesBacteriaBindingBiologicalBlood SerumCarbohydratesCessation of lifeChildChild YouthChildhoodChildren (0-21)Clinical TrialsCold-Insoluble GlobulinsCollectionColony-forming unitsComplexDataDeathDevelopmentDiseaseDisorderDoseEC 3.4.21.7ElementsEpidemiologic trendEpidemiological trendEpidemiology trendEpitheliumEquationExhibitsExocrine IgAFN1FailureFibronectin 1FibronectinsFutureGeneral PractitionersGeneralistsGoalsHabitatsHumanImmune GlobulinsImmune responseImmunityImmunizeImmunodeficient MouseImmunoglobulinsImpetigoIncidenceInfectionInfectious Skin DiseasesLETS ProteinsLarge External Transformation-Sensitive ProteinLeadLifeLong-term prospective studiesLymphatic TissueLymphoid TissueM proteinMeasuresMiceMice MammalsModelingModern ManMolecular InteractionMorbidity - disease rateMurineMusNasalNasal Passages NoseNoseOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinOrganPassive ImmunityPassive ImmunizationPathogenicity FactorsPb elementPharyngeal structurePharynxPhysiologicPhysiologicalPlasminogenPredispositionProfibrinolysinResearch ResourcesResearch SpecimenResourcesRespiratory System, Nose, Nasal PassagesRestRouteS. pyogenesSIgASecretory IgASecretory Immunoglobulin ASerologySerumSevere Combined ImmunodeficiencySevere Combined Immunodeficiency SyndromeSevere Combined Immunologic DeficiencySkinSoft Tissue InfectionsSourceSpecialistSpecificitySpecimenStandardizationStreptococcal InfectionsStreptococcal VaccinesStreptococcusStreptococcus Group AStreptococcus infectionStreptococcus pyogenesStreptolysinsSurfaceSusceptibilitySwabTestingThroatTransmissionUpper Respiratory InfectionsUpper Respiratory Tract InfectionUpper respiratory tractVaccinesVirulenceVirulence FactorsWorkadulthoodagesalpha 2-Surface Binding Glycoproteinantibody-mediated immunityautoimmune conditionautoimmune disorderautoimmunity diseasebiologiccombined T and B cell inborn immunodeficiencycomparator groupcomparison groupcutaneous infectiondevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldisease modeldisorder modelflexibilityflexiblegroup A strepheavy metal Pbheavy metal leadhost responsehuman diseasehuman subjecthuman tissuehumanized micehumanized mousehypoimmunityimmune deficiencyimmune system responseimmunodeficiencyimmunodeficient mouse modelimmunogenimmunoreactivityimmunoresponseimprovedinfected skinkidslongitudinal, prospective studymodel of animalmorbidity ratemortalitymouse modelmultiple myeloma M Proteinmurine modelnovelpassive vaccinationpathogenpediatricpre-clinical developmentpreclinical developmentprotective efficacyrelative effectivenessscreeningscreeningsskin infectiontissue woundtransmission processupper airway tractvaccine candidatevaccine developmentwoundwoundingwoundsyoungster
Description preview
ABSTRACT
The initial contact between newly transmitted group A streptococci (GAS) and its human host can be readily
thwarted by antibody (Ab) directed to the appropriate GAS antigens (Ags). To best simulate this
microenvironment, physiological (i.e., low) inoculum doses of GAS are essential. The goal of this proposal is to
identify Ags, alone and…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click