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Protection Against Nosocomial Infections After Severe Burn Injury Through Trained Immunity

Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 May 2021Deadline 30 Apr 2025 ⚠️
NIHUS FederalResearch GrantFY2025AgonistBlood leukocyteBurn injuryBurnsCause of DeathCell BodyCell Communication and SignalingCell SignalingCellsDifferential Gene ExpressionDrug TargetingDysfunctionFunctional disorderFundingGeneticGoalsHigh PrevalenceHomolog of Drosophila TOLLHospital InfectionsHospital acquired infectionHumanImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune Modulation TherapyImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmunesImmunityImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunomodulationImmunotherapeutic agentImpairmentInfectionInfection preventionIntracellular Communication and SignalingLeukocytesLeukocytes Reticuloendothelial SystemMacrophageMarrow leukocyteMediatingMetabolicMiceMice MammalsMitochondriaModern ManModificationMolecularMurineMusMyeloid CellsMφNosocomial InfectionsOxidative StressPatientsPhysiopathologyPrevent infectionResearchResistanceResistance to infectionSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStimulusTLR proteinTLR4TLR4 geneTechniquesTherapeuticTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionToll HomologueToll-Like Receptor Family GeneToll-like receptorsTrainingWhite Blood CellsWhite Cellanti-microbialantibiotic resistant pathogenantimicrobialbiological signal transductionburn modelburnedclinical applicabilityclinical applicationclinical developmentclinical relevanceclinically relevantdetermine efficacydrug resistant pathogenefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyexperiencehost responseimmune drugsimmune modulationimmune modulatory therapiesimmune modulatory treatmentimmune regulationimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune system responseimmune-based therapeuticsimmune-modulation treatmentimmunologic reactivity controlimmunologic therapeuticsimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatoryimmunomodulatory biologicsimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulationimmunoregulatoryimmunoregulatory therapyimmunoregulatory treatmentimmunoresponseimmunotherapeuticsimmunotherapy agentimprovedinfection resistanceinstitutional infectionmitochondrialparent awardparent projectpathogenpathophysiologyprogramsresistantresponseserious burnssevere burnstherapeutic immunomodulationtherapeutic immunoregulationtherapeutic targettoll-like receptor 4white blood cellwhite blood corpuscle

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Research Experience Plan
Abstract of Funded Parent Award R35 (GM141927; PI: Julia Bohannon; Funding Period: 5/1/2021-4/30/2026)
Nosocomial infections remain the leading cause of death in severely burned patients due to barrier loss, impaired
immunity, and high prevalence of antibiotic resistant pathogens. Immunomodulatory strategies aimed at…

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