grant
Prostaglandin E2-Dependent Control of a Mast Cell IL-33/ST2 Pathway in Asthma
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026Accessory SinusesAllergic to foodAllergy to foodAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAsthmaAtlasesAtopic DermatitisAtopic EczemaAtopic NeurodermatitisAttenuatedB Cell Differentiation Factor IB cell growth factor 2B-Cell Growth Factor-IIBCGF-IIBCGF2Basal CellBindingBioavailabilityBiological AvailabilityBlood SerumBody TissuesBronchial AsthmaCell Communication and SignalingCell NucleusCell ProtectionCell SignalingCell Surface ReceptorsCell surfaceChronicClinicalCytoprotectionDNA-Binding ProteinsDermatophagoides AllergensDevelopmentDinoprostoneDiseaseDisorderDisseminated NeurodermatitisDysfunctionEndothelial CellsEo-CSFEosinophil Differentiation FactorEpithelial CellsEpitheliumEquilibriumEsteroproteasesFood AllergyFood HypersensitivityFunctional disorderGeneHomologHomologHomologous GeneHomologueHouse Dust Mite AllergensIL-1 ReceptorsIL-13IL-5IL1 ReceptorsIL13IgA enhancing factorImmunityImpairmentInflammationInnate Immune ResponseInterleukin 5 PrecursorInterleukin-1 ReceptorsInterleukin-13Interleukin-5InterleukinsIntracellular Communication and SignalingLengthLungLung Respiratory SystemLymphoid CellMarrow Mast CellMediatingMembraneMiceMice MammalsMolecularMolecular InteractionMultiple PolypsMurineMusNasalNasal Passages NoseNasal SinusesNasal cavity/ParanasalNasal cavity/Paranasal sinusesNoseNucleusPGE2PGE2 alphaPGE2alphaParanasal SinusesPathologicPathway interactionsPatientsPeptidasesPeptide HydrolasesPhysiologic AvailabilityPhysiopathologyProcessProductionProstaglandin E2Prostaglandin E2 alphaProstaglandin E2alphaProtease GeneProteasesProteinasesProteinsProteolytic EnzymesPulmonary Body SystemPulmonary Organ SystemReceptor ProteinRegulationRespiratory SystemRespiratory System, Nose, Nasal PassagesRespiratory TractsRespiratory tract structureRoleSamter's triadSerumSignal TransductionSignal Transduction SystemsSignalingSinusSinusitisSiteSortingStressSyndromeT cell replacing factorT-Cell Replacing FactorTestingTherapeuticTissue BasophilsTissuesTranscriptTransgenic MiceTumorigenicityUpregulationairway epithelium inflammationairway inflammationallergic dermatitisallergic eczemaaspirin-exacerbated respiratory diseaseaspirin-induced asthmaattenuateattenuatesbalancebalance functionbiological signal transductionchronic rhinosinusitiscytokinecytoprotectivedevelopmentaldust mite allergensexpectationextracellularhuman subjectimmunopathologyin vivolipid mediatormast cellmastocytemembrane structurenew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoxidationpathophysiologypathwaypolyposispreventpreventingreceptorreceptor bindingreceptor boundrepairrepairedrespiratoryrespiratory inflammationrespiratory tract inflammationresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletherapeutic target
Description preview
Abstract
This proposal focuses on the potential role of mast cells in the control of type 2 immunopathology (T2I) elicited
by IL-33, a principal effector cytokine involved in the onset and persistence of upper and lower airway
inflammation. Preliminary studies demonstrate that mast cells are required to drive type 2 inflammation when
the levels of…
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