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Prospective contributions of the vaginal microbiome and immune milieu to spontaneous Chlamydia trachomatis clearance

Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 1 Aug 2024Deadline 24 Sept 2025 ⚠️
NIHUS FederalResearch GrantFY2025AccelerationAgeAnaerobic BacteriaAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsArchivesBacteriaBacterial VaginitisBacterial VaginosisBioinformaticsBiological Response Modifier TherapyBiological TherapyC trachomatisC. trachomatisCannot achieve a pregnancyCell AdhesionCellular AdhesionChlamydia trachomatisChronicCompensationComplexDataDevelopmentDifficulty conceivingEctopic PregnancyEnvironmentEpidemiologyEventFallopian TubesFosteringFunctional MetagenomicsGeneralized GrowthGenitourinaryGenitourinary systemGrowthGuidelinesHealth Care CostsHealth CostsIFN-GammaIFN-gIFN-γIFNGIFNγImmuneImmune InterferonImmune MarkersImmune responseImmunesImmunityImmunologic MarkersImmunologyIn VitroIndividualIndolesInfectionInfertilityInflammationInterferon GammaInterferon Type IIInterruptionInterventionKnowledgeLactic acidLactobacillusLavageLong-term infectionLongitudinal StudiesMammalian OviductsMediatingMetabolicMetabolic Clearance RateMetagenomicsMiscellaneous AntibioticModelingNational Institutes of HealthNonspecific VaginitisParentsPathologyPelvic Inflammatory DiseasePlayPopulationProductionResolutionRickettsia trachomaeRiskRoleSalpinxSamplingSexually Transmitted DiseasesSexually Transmitted DisorderSexually Transmitted InfectionTestingTissue GrowthTranslatingUnited States National Institutes of HealthUrogenitalUrogenital SystemUterine TubesVaccine DesignVaccinesVaginaVenereal DiseasesVenereal DisordersVenereal InfectionsVisitWomanWorkagedagesanaerobeanalyze microbiomebacterial disease treatmentbacterial infectious disease treatmentbiological therapeuticbiological treatmentbiologically based therapeuticsbiotherapeuticsbiotherapycervicovaginalcervicovaginal microbiomechildbearing agechronic infectionclearance ratecohortdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalepidemiologicepidemiologicalextrauterine pregnancyfertile agefertility cessationfertility lossgenital tracthost responseimmune system responseimmune-based biomarkersimmunological biomarkersimmunological markersimmunoresponseinfertileinnovateinnovationinnovativeinsightlFN-Gammalavage therapylong-term studylongitudinal outcome studiesmetagenomemicrobial consortiamicrobial floramicrobiomemicrobiome analysismicrobiotamicrofloramultiomicsmultiple omicsmultispecies consortianew approachesnon-specific vaginitisnovelnovel approachesnovel strategiesnovel strategyontogenyoviductpanomicsparentpelvic inflammation diseasepelvic inflammation disorderpelvic inflammatory disorderpelvic inflammatory syndromepersistent infectionpost-doctoral trainingpreventpreventingprospectivereproductivereproductive agereproductive tractreproductive yearsresolutionsresponsescreeningscreeningssexually acquired infectionsexually activesocial roletherapeutic targettoolvaccine developmentvaginal biomevaginal floravaginal lactobacillivaginal microbial communityvaginal microbiomevaginal microbiotavaginal microflora

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Description preview

Chlamydia trachomatis (CT) is the most common bacterial sexually transmitted infection. In the U.S., women
aged 15-24 have the highest CT burden: 782,697 cases in 2019. Up to 80% of urogenital CT infections are

asymptomatic, and untreated persistent infection can cause pelvic inflammatory disease, infertility, and ectopic

pregnancy. Risk of…

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