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PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors
Organization HARVARD UNIVERSITYLocation CAMBRIDGE, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025Active Follow-upAddressAdenomatous PolypsAlcohol Chemical ClassAlcoholsAnimal ModelAnimal Models and Related StudiesAutoregulationBiochemicalBiologic FactorBiologic ModelsBiologicalBiological FactorsBiological ModelsBody TissuesCancersCausalityCell BodyCellsChemicalsCollaborationsColonColorectal CancerColorectal NeoplasmsColorectal TumorsComputational BiologyDataDevelopmentDietDimensionsDisciplineDiseaseDisorderEcologic SystemsEcological SystemsEcosystemEnvironmentEnvironmental FactorEnvironmental Risk FactorEpidemiologic DeterminantsEpidemiologic FactorsEpidemiological FactorsEpidemiologyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyExperimental ModelsGI microbiomeGene TranscriptionGenetic TranscriptionGenomicsGoalsHomeostasisImmunologyIncidenceIndividualLarge Bowel TumorLarge Intestine NeoplasmLarge Intestine TumorLesionLife CycleLife Cycle StagesLinkMalignant NeoplasmsMalignant TumorMediatorMindModel SystemModelingModificationMolecularOncogenesisPathway interactionsPhysiologicPhysiologicalPhysiological HomeostasisPopulationPositionPositioning AttributePredispositionPreventionProcessRNA ExpressionResearchResolutionRisk AssessmentRisk FactorsSamplingSightSusceptibilityTechnologyTissuesTranscriptionTranslatingVisionWorkactive followupadenomaanti-cancer researchbiologiccancer initiationcancer progressioncancer researchcausationcohortcolorectal cancer riskcolorectal neoplasiacomputer biologydevelopmentaldietsdigestive tract microbiomedisease causationearly colo-rectal cancerearly colorectal cancerearly onsetearly onset colo-rectal cancerearly onset colorectal cancerenteric microbiomeenvironmental riskepidemiologicepidemiologicalepigeneticallyepigenomeexposomefallsfollow upfollow-upfollowed upfollowupgastrointestinal microbiomegut microbiomegut-associated microbiomehigh riskimprintinnovateinnovationinnovativeintestinal biomeintestinal microbiomelarge bowel neoplasmlife courselife spanlife style interventionlifespanlifestyle interventionmalignancymicrobialmicrobiomemodel of animalmouse modelmultiomicsmultiple omicsmurine modelneoplasm progressionneoplasm/cancerneoplastic progressionnovelobesity-promoting dietobesogenic Western-style dietobesogenic dietobesogenic high fat dietobesogenic western dietpanomicspathwaypharmacologicpolypoid adenomapreventpreventingpro-obesity dietprogenitor biologyprogenitor cell biologyresolutionsresponsescreeningscreeningssmall moleculesocial determinantssociodeterminantspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem and progenitor biologystem cell biologytumor progressiontumorigenesisvisual functionyoung colo-rectal canceryoung colorectal canceryoung onset colo-rectal canceryoung onset colorectal canceryounger age
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ABSTRACT
Our vision is to unravel and ultimately reverse the intricate network of causal factors throughout the life course
that disrupts biological homeostasis to promote colorectal cancer (CRC) among individuals younger than age 50
years. Uniting leading scientific minds in early-onset colorectal cancer (EOCRC) research and complementary
fields,…
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