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PROSPECT-Global Consortium and Risk Factor Discovery
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025AddressAdenomatous PolypsAlcohol Chemical ClassAlcoholsAnimal ModelAnimal Models and Related StudiesAutoregulationBiochemicalBiologic FactorBiologic ModelsBiologicalBiological FactorsBiological ModelsBirthBloodBlood Reticuloendothelial SystemBody TissuesCRC preventionCancersCausalityCell BodyCellsCharacteristicsChemicalsCollaborationsColonColorectal CancerComputational BiologyDNA MethylationDataDevelopmentDimensionsDisciplineEcologic SystemsEcological SystemsEcosystemElectronic Health RecordEnvironmentEnvironmental FactorEnvironmental Risk FactorEpidemiologic DeterminantsEpidemiologic FactorsEpidemiological FactorsEpidemiologyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEthnic OriginEthnicityEtiologyExposure toFecesFunctional MetagenomicsFutureGI microbiomeGene TranscriptionGenerationsGenetic TranscriptionGenomicsGeographyGoalsHomeostasisImmunologyIncidenceIndividualInterventionInvestigationLesionLife CycleLife Cycle StagesLife StyleLifestyleLinkLocationMalignant NeoplasmsMalignant TumorMediatingMetagenomicsMindModel SystemModelingModificationMolecularOncogenesisParturitionPhasePhysiologicPhysiologicalPhysiological HomeostasisPopulationPositionPositioning AttributePredispositionPreventative strategyPreventionPrevention strategyPreventive strategyProcessProspective StudiesQuestionnairesRNA ExpressionRaceRacesResearchResearch ActivityResolutionRiskRisk AssessmentRisk FactorsRoleSightSusceptibilityTechnologyTissuesTranscriptionTranslatingTransmissionUniversitiesVisionWashingtonWorkadenomaanti-cancer researchbiologicbiological specimen archivesbiosample archivebiospecimen archivecancer initiationcancer progressioncancer researchcausationcohortcolorectal cancer preventioncolorectal cancer riskcomputer biologydata harmonizationdevelopmentaldigestive tract microbiomedisease causationearly colo-rectal cancerearly colorectal cancerearly onsetearly onset colo-rectal adenomaearly onset colo-rectal cancerearly onset colorectal adenomaearly onset colorectal cancerelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordenteric microbiomeenvironmental riskepidemiologicepidemiologicalepigeneticallyepigenomeexposomegastrointestinal microbiomegut microbiomegut-associated microbiomeharmonized datahigh riskhuman dataimprintindividualized preventioninnovateinnovationinnovativeintestinal biomeintestinal microbiomelife courselife spanlife style interventionlifespanlifestyle interventionmalignancymicrobial signaturemicrobiomemodel of animalneoplasm progressionneoplasm/cancerneoplastic progressionnovelobesity-promoting dietobesogenic Western-style dietobesogenic dietobesogenic high fat dietobesogenic western dietpersonalized preventionpharmacologicpolypoid adenomaprecision preventionprevent colorectal cancerpro-obesity dietprogenitor biologyprogenitor cell biologyracialracial backgroundracial originresolutionsresponsesmall moleculesocialsocial determinantssocial rolesociodeterminantspecimen archivestem and progenitor biologystem cell biologystooltransmission processtumor initiationtumor progressiontumorigenesisvisual functionyoung colo-rectal canceryoung colorectal canceryoung onset colo-rectal canceryoung onset colorectal canceryounger age
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ABSTRACT
Our vision is to unravel and ultimately reverse the intricate network of causal factors throughout the life course
that disrupts biological homeostasis to promote colorectal cancer (CRC) among individuals younger than age 50
years. Uniting leading scientific minds in early-onset colorectal cancer (EOCRC) research and complementary
fields,…
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