grant
Propionate metabolism and cancer
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 25 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AddressAgeAreaAutocrine SystemsAutomobile DrivingBiochemicalBiological FunctionBiological MarkersBiological ProcessBiologyBlood SerumBranched-Chain Amino AcidsBreast Cancer CellCancer BiologyCancer TreatmentCancersCause of DeathCell BodyCell Communication and SignalingCell SignalingCellsCessation of lifeChemoresistanceCommunicationCoupledDNA mutationDataDeathDevelopmentDicarboxylic AcidsDiseaseDisorderDisseminated Malignant NeoplasmDrug TargetingDrug resistanceERK 2ERK2ERT1ElderlyEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsExpression ProfilingExtracellular Signal-Regulated Kinase 2Fatty AcidsFibroblastsGene ExpressionGene TranscriptionGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsHereditary DiseaseHereditary Metabolic DisorderHypoxiaHypoxicIn VitroInborn Errors of MetabolismInborn Genetic DiseasesInherited disorderIntermediary MetabolismIntracellular Communication and SignalingKnowledgeLinkMAP Kinase 1MAP Kinase 2MAPK1MAPK1 Mitogen-Activated Protein KinaseMAPK1 geneMAPK2MAPK2 Mitogen-Activated Protein KinaseMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMesenchymalMetabolicMetabolic PathwayMetabolic ProcessesMetabolic dysfunctionMetabolismMetastasisMetastasizeMetastatic CancerMetastatic LesionMetastatic Malignant NeoplasmMetastatic MassMetastatic NeoplasmMetastatic TumorMethylmalonic AcidMethylmalonyl-CoA IsomeraseMethylmalonyl-CoA MutaseMitogen Activated Protein Kinase 1Mitogen-Activated Protein Kinase 2MolecularMutationNeoplasm MetastasisOncologyOncology CancerOrganism-Level ProcessOrganismal ProcessOxygen DeficiencyP41MAPKP42MAPKPRKM1PRKM2Pathway interactionsPatientsPersonsPhenotypePhysiologic ProcessesPhysiological ProcessesPrimary NeoplasmPrimary TumorProcessProductionPropertyPropionatesPropionyl-CoA CarboxylasePropionyl-Coenzyme A CarboxylaseProteomicsPublishingRNA ExpressionRegulator GenesSecondary NeoplasmSecondary TumorSerumSignal TransductionSignal Transduction SystemsSignalingSolid NeoplasmSolid TumorTestingTherapeutic InterventionTimeTranscriptionTranscriptional Regulatory ElementsTumor CellTumor PromotionWorkWound Repairadvanced ageage associatedage correlatedage dependentage linkedage relatedage specificagesanti-cancer therapyautocrinebio-markersbiologic markerbiological signal transductionbiomarkerbiomarker identificationbranched amino acidsbreast tumor cellcancer cellcancer metastasiscancer microenvironmentcancer progressioncancer therapycancer-directed therapychemoresistantchemotherapy resistancechemotherapy resistantdevelopmentaldrivingdrug discoverydrug resistantepigeneticallyepimeraseepithelial to mesenchymal transitionexpectationextracellulargenetic trans acting elementgenome mutationgeriatrichereditary disorderheritable disorderidentification of biomarkersidentification of new biomarkersimprovedin vivoin vivo Modelinborn errorinborn metabolism disorderindividualized therapeuticinherited diseasesinherited genetic diseaseinherited genetic disorderinsightintervention therapylung cancer cellmalignancymarker identificationmetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmethyl-propanedioic acidmethylmalonic acidemiamethylmalonic aciduriamethylmalonyl CoAmethylmalonyl-CoA decarboxylasemethylmalonyl-coenzyme Amortalityneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnon-geneticnongeneticnovelnutrient deprivationnutritional deprivationp42 MAP Kinasep42 MAPKparacrinepathwaypersonalized therapeuticpreventpreventingprogramspropionyl-CoApropionyl-coenzyme Aregulatory generesistance to Drugresistant to Drugsenior citizentargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettrans acting elementtranscriptomicstumortumor cell metastasistumor growthtumor microenvironmenttumor progressionwound healingwound recoverywound resolution
Description preview
SUMMARY (30 lines max)
The vast majority of cancer mortality is due to metastases. A major unmet need in oncology is how to predict
and prevent metastatic progression. To address this need, it is imperative we advance our understanding of how
tumor cells acquire metastatic capability. Epithelial-to-mesenchymal transition (EMT) is a normal…
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